"Sp1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
| Descriptor ID |
D016329
|
| MeSH Number(s) |
D12.776.260.522.750.249 D12.776.930.375.750.249
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Sp1 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp1 Transcription Factor".
This graph shows the total number of publications written about "Sp1 Transcription Factor" by people in this website by year, and whether "Sp1 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sp1 Transcription Factor" by people in Profiles.
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SP1-induced long non-coding RNA SNHG6 facilitates the carcinogenesis of chondrosarcoma through inhibiting KLF6 by recruiting EZH2. Cell Death Dis. 2021 01 11; 12(1):59.
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DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. Circulation. 2020 02 25; 141(8):655-666.
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Sp1 regulates steroidogenic genes and LHCGR expression in primary human luteinized granulosa cells. J Steroid Biochem Mol Biol. 2019 06; 190:183-192.
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cis-regulatory architecture of a short-range EGFR organizing center in the Drosophila melanogaster leg. PLoS Genet. 2018 08; 14(8):e1007568.
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MiR-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte-Like Fate by Directly Repressing Specificity Protein 1. J Am Heart Assoc. 2016 11 10; 5(11).
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PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21. Oncotarget. 2015 Jul 30; 6(21):18469-83.
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GADD45a promoter regulation by a functional genetic variant associated with acute lung injury. PLoS One. 2014; 9(6):e100169.
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SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome. J Clin Invest. 2014 Apr; 124(4):1512-24.
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Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk. PLoS One. 2013; 8(4):e61279.
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The RB tumor suppressor positively regulates transcription of the anti-angiogenic protein NOL7. Neoplasia. 2012 Dec; 14(12):1213-22.