Loss of cleavage at ß'-site contributes to apparent increase in ß-amyloid peptide (Aß) secretion by ß-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Loss of cleavage at ß'-site contributes to apparent increase in ß-amyloid peptide (Aß) secretion by ß-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein. J Biol Chem. 2011 Jul 22; 286(29):26166-77.

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subject areas

Amino Acid Sequence
Amyloid beta-Peptides
Amyloid Precursor Protein Secretases
Animals
Aspartic Acid Endopeptidases
Binding Sites
Cell Membrane
Gene Expression Regulation, Enzymologic
Glycosylphosphatidylinositols
HEK293 Cells
Humans
Mice
Molecular Dynamics Simulation
Molecular Sequence Data
Mutagenesis
Mutation
Peptide Fragments
Protein Structure, Tertiary
Solubility
Substrate Specificity

authors with profiles

Kulandaivelu Vetrivel