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Rajesh Jain

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Endocrinology
AddressChicago IL 60637
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    Collapse Overview 
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    Rajesh K. Jain, MD, specializes in endocrinology and focuses on metabolic bone diseases. This includes osteoporosis, osteopenia, calcium disorders (including hyperparathyroidism and hypoparathyroidism), Vitamin D deficiency, Paget's disease, and other metabolic bone disease. He is certified by the International Society of Clinical Densitometry to read and interpret bone density testing.

    Dr. Jain conducts research in a variety of areas within osteoporosis and metabolic bone disease. Some of the areas he conducts research in include trabecular bone score, the effects of physical activity and body fat on bone, diabetes-related fracture risk, and differences in fracture risk factors in racial and ethnic minorities. He is also an investigator for clinical trials in hypoparathyroidism.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Balasubaramaniam V, Mun Wong GY, Martinino A, Sarodaya V, Abulazayem M, Wazir I, Scarano Pereira JP, Marques CN, Said A, Wadhawan H, Graham Y, Jain RK, Riera M, Mahdi AS, Ammar AS, Mohamed A, Alfarwan A, Sanli AN, Aymar A, Alkaseek A, Khamees A, Ouyahia A, Kosti A, Dawle A, Maqbool B, Abdelhadi B, Parmar C, Colak E, Erginoz E, Verras GI, Abd El Hady HG, Hamdan HKH, Bakeer HB, Alhadad HS, Elzayat I, Gerogiannis I, Demma JA, Al-Shami K, Shalabi L, Frountzas M, Manoj MA, Tokocin M, Campanelli M, Omar MA, Farag Karamelghani MA, Rais M, Abu Jayyab MA, Allahverdiyeva N, Gentileschi P, Abizade R, Huseynov S, Das A, Uludag SS, Cyclewala SS, Meric S, Omarov T, Bakewell ZR, Singhal R, Mahawar K, STANMORE Study Collaborative Group. Thirty-Day Mortality and Morbidity Outcomes in Abdominal Wall Necrotizing Soft Tissue Infections: The STANMORE Study. World J Surg. 2026 Sep 10. PMID: 42723299.
      Citations:    
    2. Jain RK, Polley E, Vokes T. Race-Neutral FRAX without BMD outperforms FRAX without BMD in a multiethnic cohort with Diabetes or Hypertension. J Bone Miner Res. 2026 Jun 19. PMID: 42319028.
      Citations:    Fields:    
    3. Tobias J, Azar SA, Michelakos T, Kaylan K, Nordgren R, Drake FT, Keutgen XM, Angelos P, Jain R, Applewhite MK. Bone mineral density outcomes after parathyroidectomy in primary hyperparathyroidism and osteopenia: A meta-analysis and metaregression. Surgery. 2026 Aug; 196:110254. PMID: 42134072.
      Citations:    Fields:    Translation:Humans
    4. Khan AA, Rejnmark L, Jain R, Pihl S, Breinholt VM, Zhao C, Lai B, Ukena J, Sibley CT, Shu AD. Pharmacodynamics of sustained levels of PTH following palopegteriparatide treatment in adults with hypoparathyroidism. J Endocr Soc. 2026 Jul; 10(7):bvag098. PMID: 42440695; PMCID: PMC13334101.
      Citations:    
    5. Alemu LS, Chopra K, Jain RK. Visceral adiposity does not explain increased diabetes rates in Black and Hispanic people in NHANES 2011-2018. J Endocr Soc. 2026 Apr; 10(4):bvag025. PMID: 41929382; PMCID: PMC13043143.
      Citations:    
    6. Jain RK. Changes in treatment eligibility with race-neutral US FRAX would be modest: estimates using the National Health and Nutrition Examination Survey (NHANES). Osteoporos Int. 2026 Feb; 37(2):481-490. PMID: 41392042; PMCID: PMC12956982.
      Citations:    Fields:    Translation:Humans
    7. Dickens LT, Abe CM, Connors M, Osman F, Abdelaziz S, Duge LS, Jain RK. Osteoporosis Epidemiology, Diagnosis, and Management Across Race and Ethnicity in the United States. J Clin Endocrinol Metab. 2025 11 18; 110(12):3309-3321. PMID: 40820822.
      Citations: 2     Fields:    Translation:Humans
    8. Saeed J, Jamal Z, Siddiqui A, Muawaz M, Saeed T, Jain RK. Postoperative Outcomes of the Desarda Technique Versus Lichtenstein Mesh Repair for Inguinal Hernias: A Systematic Review and Meta-Analysis. Cureus. 2025 Sep; 17(9):e91388. PMID: 41040752; PMCID: PMC12486189.
      Citations:    
    9. Balasubaramaniam V, Wong GYM, Martinino A, Riera M, Abouelazayem M, Pereira JPS, Said A, Graham Y, Jain RK, Imseeh H, Aljaiuossi O, Jayyab MAA, Alyacoubi SNA, Mahawar K, Singhal R, MORSE Study Collaborative Group. Mortality Related to Bariatric Surgery (MORSE Study): A Retrospective, International Collaborative Audit. Clin Obes. 2025 Dec; 15(6):e70031. PMID: 40530608.
      Citations:    Fields:    Translation:Humans
    10. Saxena P, Arora SK, Prakash A, Chawla R, Chandrasekar A, Diwakar H, Jain R, Seshiah V. Targeting Global Coverage: Comparison of In-Hospital OGTT at 2-3 Days Postpartum with OGTT at 6-12 Weeks Postpartum for Predicting Glucose Intolerance in Postpartum Women with Gestational Diabetes Mellitus. J Obstet Gynaecol India. 2025 Jun; 75(3):253-257. PMID: 40584796; PMCID: PMC12204957.
      Citations:    Fields:    
    11. Jain RK, Liu JY, Grant RW, Haider S, Huang ES, Laiteerapong N, Lipska KJ, Lo JC, Moffet HH, Parker MM, Karter AJ. Biases in the performance of FRAX without BMD in predicting fracture risk in a multiethnic population with diabetes: the Diabetes and Aging Study. J Bone Miner Res. 2025 Apr 21; 40(4):478-491. PMID: 39876767; PMCID: PMC12010159.
      Citations: 2     Fields:    Translation:Humans
    12. Parker MM, Lipska KJ, Gilliam LK, Grant RW, Haider S, Huang ES, Jain RK, Laiteerapong N, Liu JY, Moffet HH, Karter AJ. Deprescribing in Older Adults With Type 2 Diabetes: Associations With Patients' Perspectives: The Diabetes and Aging Study. J Am Geriatr Soc. 2025 04; 73(4):1155-1167. PMID: 39781584; PMCID: PMC11971003.
      Citations: 3     Fields:    Translation:Humans
    13. López Picazo M, Humbert L, Jain RK, Dickens L, Vokes T. Bone Structural Parameters as Measured by 3-Dimensional Dual-Energy X-Ray Absorptiometry Are Superior in Black Women and Demonstrate Unique Associations With Prior Fracture Versus White Women. Endocr Pract. 2025 Feb; 31(2):152-158. PMID: 39521249.
      Citations: 1     Fields:    Translation:Humans
    14. Dickens LT, Jain RK. An Update on the Fracture Risk Assessment Tool: What Have We Learned over 15+ years? Endocrinol Metab Clin North Am. 2024 Dec; 53(4):531-545. PMID: 39448135.
      Citations: 3     Fields:    Translation:Humans
    15. Jain RK. Comment on article "Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force Report on Clinical Algorithms for Fracture Risk". Osteoporos Int. 2024 Dec; 35(12):2235-2236. PMID: 39227448.
      Citations:    Fields:    
    16. Jain RK, Polley E, Weiner M, Iwamaye A, Huang E, Vokes T. An electronic health record (EHR)-based risk calculator can predict fractures comparably to FRAX: a proof-of-concept study. Osteoporos Int. 2024 Dec; 35(12):2117-2126. PMID: 39147872; PMCID: PMC12777739.
      Citations: 1     Fields:    Translation:Humans
    17. Abouelazayem M, Jain R, Wilson MSJ, Martinino A, Balasubaramaniam V, Biffl W, Coccolini F, Riera M, Wadhawan H, Wazir I, Abderaouf B, Abramov D, Abu Jayyab MA, Al-Shami K, Alfarwan A, Alhajami FM, Alkaseek A, Alozairi O, Ammar AS, Atar B, Baatarjav GE, Bains L, Bakri A, Bayramov N, Bhojwani R, Brachini G, Calini G, Campanelli M, Cheng SY, Choudhary CS, Chowdhury S, Colak E, Das JK, Dawani S, Dönmez T, Elzayat I, Erdene S, Faizi TQ, Frountzas M, Gafsi B, Gentileschi P, Guler M, Gupta G, Harkati NE, Harris M, Hasan DM, Irowa OO, Jafferi S, Jain SA, Jun Han L, Kandiboyina SM, Karabulut M, Khamees A, Khan S, Khan MM, Khaw CJ, Kisielewski M, Klib M, Košir JA, Krawczyk WJ, Lisi G, Makama JG, Maqbool B, Marques CN, Meric S, Mietla MP, Ads AM, Muhumuza J, Mulita F, Mustafayeva M, Omar MA, Omarov T, Pathak AA, Paul R, Pavone G, Podda M, Raja Ram NK, Rauf F, Rauf S, Safy AM, Sandag E, Sanli AN, Siddiqui AZ, Sotiropoulou M, Talib V, Tatar C, Thota A, Tokocin M, Tolat A, Uchikov PA, Valenzuela JI, Venkatappa SK, Verras GI, Vlahovic I, Zreeg DAS, Cardoso VR, Gkoutos GV, Singhal R, Mahawar K, GRACE Study Collaborative Group. Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study. Surg Endosc. 2024 08; 38(8):4402-4414. PMID: 38886232.
      Citations: 9     Fields:    Translation:Humans
    18. Haider S, Parker MM, Huang ES, Grant RW, Moffet HH, Laiteerapong N, Jain RK, Liu JY, Lipska KJ, Karter AJ. Willingness to take less medication for type 2 diabetes among older patients: The Diabetes & Aging Study. J Am Geriatr Soc. 2024 07; 72(7):1985-1994. PMID: 38471959; PMCID: PMC11226366.
      Citations: 1     Fields:    Translation:Humans
    19. Jain RK, Weiner M, Polley E, Iwamaye A, Huang E, Vokes T. Electronic Health Records (EHRs) Can Identify Patients at High Risk of Fracture but Require Substantial Race Adjustments to Currently Available Fracture Risk Calculators. J Gen Intern Med. 2023 12; 38(16):3451-3459. PMID: 37715097; PMCID: PMC10713897.
      Citations: 5     Fields:    Translation:Humans
    20. Liu J, Angelos P, Barhoum M, Jain R. Severe Hypercalcemia Due to Primary Hyperparathyroidism and Heterozygous Pathogenic Variant of CYP24A1. JCEM Case Rep. 2023 Jul; 1(4):luad071. PMID: 37909006; PMCID: PMC10578407.
      Citations: 2     
    21. Jain RK, Vokes T. Visceral Adipose Tissue is Negatively Associated With Bone Mineral Density in NHANES 2011-2018. J Endocr Soc. 2023 Feb 09; 7(4):bvad008. PMID: 36793478; PMCID: PMC9922944.
      Citations: 18     
    22. Jain R, Bhavatharini N, Saravanan T, Seshiah V, Jain N. Use of Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitor Remogliflozin and Possibility of Acute Kidney Injury in Type-2 Diabetes. Cureus. 2022 Dec; 14(12):e32573. PMID: 36654590; PMCID: PMC9840745.
      Citations: 3     
    23. Jain RK, Vokes T. Fat Mass Has Negative Effects on Bone, Especially in Men: A Cross-sectional Analysis of NHANES 2011-2018. J Clin Endocrinol Metab. 2022 05 17; 107(6):e2545-e2552. PMID: 35142799.
      Citations: 20     Fields:    Translation:Humans
    24. Jain RK, Vokes T. Comment on article "Race/ethnic difference in trabecular bone score in midlife women: The Study of Women's Health Across the Nation (SWAN)". Osteoporos Int. 2022 04; 33(4):949-950. PMID: 35075498.
      Citations:    Fields:    Translation:Humans
    25. Jain RK, Vokes T. BMDs Derived From Total Body DXA are Strongly Correlated With Dedicated Hip and Spine BMD and are Associated With Prior Fractures in NHANES. J Clin Densitom. 2022 Jul-Sep; 25(3):349-356. PMID: 34996720.
      Citations: 3     Fields:    Translation:Humans
    26. Seshiah V, Balaji V, Bronson SC, Jain R, Chandrasekar A. Diagnosing Gestational Diabetes by a Single-Test Procedure Is a Propitious Step Towards Containing the Epidemic of Diabetes. Cureus. 2021 Nov; 13(11):e19910. PMID: 34976516; PMCID: PMC8712238.
      Citations:    
    27. Singhal R, Ludwig C, Rudge G, Gkoutos GV, Tahrani A, Mahawar K, GENEVA Collaborators, Pedziwiatr M, Major P, Zarzycki P, Pantelis A, Lapatsanis DP, Stravodimos G, Matthys C, Focquet M, Vleeschouwers W, Spaventa AG, Zerrweck C, Vitiello A, Berardi G, Musella M, Sanchez-Meza A, Cantu FJ, Mora F, Cantu MA, Katakwar A, Reddy DN, Elmaleh H, Hassan M, Elghandour A, Elbanna M, Osman A, Khan A, Layani L, Kiran N, Velikorechin A, Solovyeva M, Melali H, Shahabi S, Agrawal A, Shrivastava A, Sharma A, Narwaria B, Narwaria M, Raziel A, Sakran N, Susmallian S, Karagöz L, Akbaba M, Piskin SZ, Balta AZ, Senol Z, Manno E, Iovino MG, Osman A, Qassem M, Arana-Garza S, Povoas HP, Vilas-Boas ML, Naumann D, Super J, Li A, Ammori BJ, Balamoun H, Salman M, Nasta AM, Goel R, Sánchez-Aguilar H, Herrera MF, Abou-Mrad A, Cloix L, Mazzini GS, Kristem L, Lazaro A, Campos J, Bernardo J, González J, Trindade C, Viveiros O, Ribeiro R, Goitein D, Hazzan D, Segev L, Beck T, Reyes H, Monterrubio J, García P, Benois M, Kassir R, Contine A, Elshafei M, Aktas S, Weiner S, Heidsieck T, Level L, Pinango S, Ortega PM, Moncada R, Valenti V, Vlahovic I, Boras Z, Liagre A, Martini F, Juglard G, Motwani M, Saggu SS, Al Moman H, López LAA, Cortez MAC, Zavala RA, D'Haese C, Kempeneers I, Himpens J, Lazzati A, Paolino L, Bathaei S, Bedirli A, Yavuz A, Büyükkasap Ç, Özaydin S, Kwiatkowski A, Bartosiak K, Waledziak M, Santonicola A, Angrisani L, Iovino P, Palma R, Iossa A, Boru CE, De Angelis F, Silecchia G, Hussain A, Balchandra S, Coltell IB, Pérez JL, Bohra A, Awan AK, Madhok B, Leeder PC, Awad S, Al-Khyatt W, Shoma A, Elghadban H, Ghareeb S, Mathews B, Kurian M, Larentzakis A, Vrakopoulou GZ, Albanopoulos K, Bozdag A, Lale A, Kirkil C, Dincer M, Bashir A, Haddad A, Hijleh LA, Zilberstein B, de Marchi DD, Souza WP, Brodén CM, Gislason H, Shah K, Ambrosi A, Pavone G, Tartaglia N, Kona SLK, Kalyan K, Perez CEG, Botero MAF, Covic A, Timofte D, Maxim M, Faraj D, Tseng L, Liem R, Ören G, Dilektasli E, Yalcin I, AlMukhtar H, Al Hadad M, Mohan R, Arora N, Bedi D, Rives-Lange C, Chevallier JM, Poghosyan T, Sebbag H, Zinaï L, Khaldi S, Mauchien C, Mazza D, Dinescu G, Rea B, Pérez-Galaz F, Zavala L, Besa A, Curell A, Balibrea JM, Vaz C, Galindo L, Silva N, Caballero JLE, Sebastian SO, Marchesini JCD, da Fonseca Pereira RA, Sobottka WH, Fiolo FE, Turchi M, Coelho ACJ, Zacaron AL, Barbosa A, Quinino R, Menaldi G, Paleari N, Martinez-Duartez P, de Aragon Ramírez de Esparza GM, Esteban VS, Torres A, Garcia-Galocha JL, Josa M, Pacheco-Garcia JM, Mayo-Ossorio MA, Chowbey P, Soni V, de Vasconcelos Cunha HA, Castilho MV, Ferreira RMA, Barreiro TA, Charalabopoulos A, Sdralis E, Davakis S, Bomans B, Dapri G, Van Belle K, Takieddine M, Vaneukem P, Karaca ESA, Karaca FC, Sumer A, Peksen C, Savas OA, Chousleb E, Elmokayed F, Fakhereldin I, Aboshanab HM, Swelium T, Gudal A, Gamloo L, Ugale A, Ugale S, Boeker C, Reetz C, Hakami IA, Mall J, Alexandrou A, Baili E, Bodnar Z, Maleckas A, Gudaityte R, Guldogan CE, Gundogdu E, Ozmen MM, Thakkar D, Dukkipati N, Shah PS, Shah SS, Shah SS, Adil MT, Jambulingam P, Mamidanna R, Whitelaw D, Adil MT, Jain V, Veetil DK, Wadhawan R, Torres A, Torres M, Tinoco T, Leclercq W, Romeijn M, van de Pas K, Alkhazraji AK, Taha SA, Ustun M, Yigit T, Inam A, Burhanulhaq M, Pazouki A, Eghbali F, Kermansaravi M, Jazi AHD, Mahmoudieh M, Mogharehabed N, Tsiotos G, Stamou K, Barrera Rodriguez FJ, Rojas Navarro MA, Torres OM, Martinez SL, Tamez ERM, Millan Cornejo GA, Flores JEG, Mohammed DA, Elfawal MH, Shabbir A, Guowei K, So JB, Kaplan ET, Kaplan M, Kaplan T, Pham D, Rana G, Kappus M, Gadani R, Kahitan M, Pokharel K, Osborne A, Pournaras D, Hewes J, Napolitano E, Chiappetta S, Bottino V, Dorado E, Schoettler A, Gaertner D, Fedtke K, Aguilar-Espinosa F, Aceves-Lozano S, Balani A, Nagliati C, Pennisi D, Rizzi A, Frattini F, Foschi D, Benuzzi L, Parikh C, Shah H, Pinotti E, Montuori M, Borrelli V, Dargent J, Copaescu CA, Hutopila I, Smeu B, Witteman B, Hazebroek E, et al. 30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries. Obes Surg. 2021 10; 31(10):4272-4288. PMID: 34328624; PMCID: PMC8323543.
      Citations: 25     Fields:    Translation:HumansCellsPHPublic Health
    28. Seshiah V, Balaji V, Banerjee S, Sahay R, Divakar H, Jain R, Chawla R, Das AK, Gupta S, Krishnan D. Diagnosis and principles of management of gestational diabetes mellitus in the prevailing COVID-19 pandemic. Int J Diabetes Dev Ctries. 2020 Sep; 40(3):329-334. PMID: 32929316; PMCID: PMC7480657.
      Citations: 7     
    29. Jain RK, Weiner MG, Zhao H, Vokes T. Comorbid Conditions and GFR Predict Nonvertebral Fractures in Patients With Diabetes in an Ethnic-Specific Manner. J Clin Endocrinol Metab. 2020 06 01; 105(6). PMID: 32193529.
      Citations: 1     Fields:    Translation:Humans
    30. Jain RK, Weiner MG, Zhao H, Williams KJ, Vokes T. Diabetes-Related Fracture Risk Is Different in African Americans Compared With Hispanics and Caucasians. J Clin Endocrinol Metab. 2019 11 01; 104(11):5729-5736. PMID: 31369094.
      Citations: 4     Fields:    Translation:Humans
    31. Seshiah V, Shah SS, Balaji V, Anjalakshi C, Jain R. When are we Going to Settle the Diagnostic Criteria of Gestational Diabetes Mellitus? J Assoc Physicians India. 2019 Oct; 67(10):70-72. PMID: 31571457.
      Citations: 1     Fields:    Translation:Humans
    32. Jain RK, Vokes T. Physical activity as measured by accelerometer in NHANES 2005-2006 is associated with better bone density and trabecular bone score in older adults. Arch Osteoporos. 2019 03 02; 14(1):29. PMID: 30826896.
      Citations: 15     Fields:    Translation:Humans
    33. Jain RK, Vokes T. The Prediction of Body Composition in African Americans From Spine and Hip Dual-Energy Absorptiometry. J Clin Densitom. 2019 Jul - Sep; 22(3):444-450. PMID: 29173816.
      Citations: 1     Fields:    Translation:Humans
    34. Jain RK, Vokes T. Dual-energy X-ray Absorptiometry. J Clin Densitom. 2017 Jul - Sep; 20(3):291-303. PMID: 28716497.
      Citations: 64     Fields:    Translation:Humans
    35. Zeytinoglu M, Jain RK, Vokes TJ. Vertebral fracture assessment: Enhancing the diagnosis, prevention, and treatment of osteoporosis. Bone. 2017 Nov; 104:54-65. PMID: 28285014.
      Citations: 34     Fields:    Translation:Humans
    36. Jain RK, Bennet B, Vokes T. Ethnic Differences in Osteoporosis After Cardiac Transplantation. J Clin Densitom. 2017 Apr - Jun; 20(2):164-171. PMID: 27595486.
      Citations:    Fields:    Translation:Humans
    37. Jain RK, Narang DK, Hans D, Vokes TJ. Ethnic Differences in Trabecular Bone Score. J Clin Densitom. 2017 Apr - Jun; 20(2):172-179. PMID: 27160503.
      Citations: 11     Fields:    Translation:Humans
    38. Jain RK, Laiteerapong N. Strategies for improving cardiovascular health in women with diabetes mellitus: a review of the evidence. Curr Diab Rep. 2015 Nov; 15(11):98. PMID: 26391392; PMCID: PMC4886737.
      Citations: 1     Fields:    Translation:HumansAnimals
    39. Kumar M, Thukral A, Jain R, Chaudhary S, Mukherjee S, Chowdhury S. Comments on 'Effect of pioglitazone on testosterone in eugonadal men with type 2 diabetes mellitus: a randomized double-blind placebo controlled study'. Clin Endocrinol (Oxf). 2014 Jan; 80(1):157. PMID: 23550924.
      Citations:    Fields:    Translation:Humans
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