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Eric Polley

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentPublic Health Sciences
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Director, Biostatistics Laboratory

    Eric Polley, PhD is an Associate Professor in the Department of Public Health Sciences at The University of Chicago where he is the faculty director for the Data Science concentration in the Master of Public Health program. Dr. Polley was previously an Assistant Professor of Biostatistics in the Department of Quantitative Health Sciences at Mayo Clinic (2015-2021) and a mathematical statistician in the Biometric Research Branch at the U.S. National Cancer Institute (2012-2015). Dr. Polley received his PhD in biostatistics from the University of California, Berkeley in 2010. With Mark van der Laan, they developed the Super Learner ensemble prediction methodology. His research area involves the development and evaluation of prediction methods, innovative methods for diagnostic and prognostic prediction, and precision medicine clinical trial design.

    Collapse Biography 
    Collapse education and training
    Saint John's University, MNBA2003Mathematics
    Columbia University, NYMS2005Biostatistics
    University of California, Berkeley, CAPhD2010Biostatistics
    National Cancer Institute, MDFellow2012Computational Biology
    Collapse awards and honors
    2015NCI Director's award for the development of the NCI-MATCH clinical trial, National Cancer Institute

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang H, Couch RE, Karam R, Hu C, Boddicker N, Polley EC, Na J, Ambrosone CB, Yao S, Trentham-Dietz A, Eliassen AH, Penney K, Brantley K, Bodelon C, Teras LR, Hodge J, Patel A, Haiman CA, John EM, Neuhausen SL, Martinez E, Lacey JV, O'Brien KM, Sandler DP, Weinberg CR, Palmer JR, Bertrand KA, Vachon CM, Olson JE, Ruddy KE, Anton-Culver H, Ziogas A, Goldgar DE, Nathanson KL, Domchek SM, Weitzel JN, Kraft P, Dolinsky JS, Pesaran T, Richardson ME, Yadav S, Couch FJ. Pathogenic variants in cancer susceptibility genes predispose to Ductal Carcinoma In situ of the breast. Clin Cancer Res. 2024 Nov 08. PMID: 39513960.
      Citations:    
    2. Zhao F, Polley E, McClellan J, Howard F, Olopade OI, Huo D. Predicting pathologic complete response to neoadjuvant chemotherapy in breast cancer using a machine learning approach. Breast Cancer Res. 2024 Oct 29; 26(1):148. PMID: 39472970; PMCID: PMC11520773.
      Citations:    Fields:    Translation:Humans
    3. Lin K, Michaels E, Polley E, O'Donnell PH, Howard FM, Hahn O, Fleming GF, Nanda R, Chen N, Yang H. Retrospective evaluation of adjuvant capecitabine dosing patterns in triple negative breast cancer. J Oncol Pharm Pract. 2024 Oct 13; 10781552241289581. PMID: 39397422.
      Citations:    Fields:    
    4. Akamandisa MP, Boddicker NJ, Yadav S, Hu C, Hart SN, Ambrosone C, Anton-Culver H, Auer PL, Bodelon C, Burnside ES, Chen F, Eliassen HA, Goldgar DE, Haiman C, Hodge JM, Huang H, John EM, Karam R, Lacey JV, Lindstroem S, Martinez E, Na J, Neuhausen SL, O'Brien KM, Olson JE, Pal T, Palmer JR, Patel AV, Pesaran T, Polley EC, Richardson ME, Ruddy K, Sandler DP, Teras LR, Trentham-Dietz A, Vachon CM, Weinberg C, Winham SJ, Yao S, Zirpoli G, Kraft P, Weitzel JN, Domchek SM, Couch FJ, Nathanson KL. Association of Gene Variant Type and Location with Breast Cancer Risk in the General Population. medRxiv. 2024 Oct 12. PMID: 39417132; PMCID: PMC11482981.
      Citations:    
    5. Zanti M, O'Mahony DG, Parsons MT, Dorling L, Dennis J, Boddicker NJ, Chen W, Hu C, Naven M, Yiangou K, Ahearn TU, Ambrosone CB, Andrulis IL, Antoniou AC, Auer PL, Baynes C, Bodelon C, Bogdanova NV, Bojesen SE, Bolla MK, Brantley KD, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chang-Claude J, Chen F, Chenevix-Trench G, NBCS Collaborators, Conroy DM, Czene K, De Nicolo A, Domchek SM, Dörk T, Dunning AM, Eliassen AH, Evans DG, Fasching PA, Figueroa JD, Flyger H, Gago-Dominguez M, García-Closas M, Glendon G, González-Neira A, Grassmann F, Hadjisavvas A, Haiman CA, Hamann U, Hart SN, Hartman MBA, Ho WK, Hodge JM, Hoppe R, Howell SJ, kConFab Investigators, Jakubowska A, Khusnutdinova EK, Ko YD, Kraft P, Kristensen VN, Lacey JV, Li J, Lim GH, Lindström S, Lophatananon A, Luccarini C, Mannermaa A, Martinez ME, Mavroudis D, Milne RL, Muir K, Nathanson KL, Nuñez-Torres R, Obi N, Olson JE, Palmer JR, Panayiotidis MI, Patel AV, Pharoah PDP, Polley EC, Rashid MU, Ruddy KJ, Saloustros E, Sawyer EJ, Schmidt MK, Southey MC, Tan VK, Teo SH, Teras LR, Torres D, Trentham-Dietz A, Truong T, Vachon CM, Wang Q, Weitzel JN, Yadav S, Yao S, Zirpoli GR, Cline MS, Devilee P, Tavtigian SV, Goldgar DE, Couch FJ, Easton DF, Spurdle AB, Michailidou K. Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification. medRxiv. 2024 Sep 04. PMID: 39281752; PMCID: PMC11398439.
      Citations:    
    6. Jain RK, Polley E, Weiner M, Iwamaye A, Huang E, Vokes T. An electronic health record (EHR)-based risk calculator can predict fractures comparably to FRAX: a proof-of-concept study. Osteoporos Int. 2024 Aug 15. PMID: 39147872.
      Citations:    Fields:    
    7. Powla PP, Fakhri F, Jankowski S, Mansour A, Polley EC. Clinical Prediction Models in Neurocritical Care: An Overview of the Literature and Example Application to Prediction of Hospital Mortality in Traumatic Brain Injury. Neurocrit Care. 2024 Aug 06. PMID: 39107660.
      Citations:    Fields:    
    8. Fasching PA, Hu C, Hart SN, Ruebner M, Polley EC, Gnanaolivu RD, Hartkopf AD, Huebner H, Janni W, Hadji P, Tesch H, Uhrig S, Ettl J, Lux MP, Lüftner D, Wallwiener M, Wurmthaler LA, Goossens C, Müller V, Beckmann MW, Hein A, Anetsberger D, Belleville E, Wimberger P, Untch M, Ekici AB, Kolberg HC, Hartmann A, Taran FA, Fehm TN, Wallwiener D, Brucker SY, Schneeweiss A, Häberle L, Couch FJ. Susceptibility gene mutations in germline and tumors of patients with HER2-negative advanced breast cancer. NPJ Breast Cancer. 2024 Jul 13; 10(1):57. PMID: 39003306; PMCID: PMC11246424.
      Citations:    
    9. Issa NP, Aydin S, Polley E, Carberry N, Garret MA, Smith S, Habib AA, Baumgartner NW, Soliven B, Rezania K. Intermuscular coherence as an early biomarker for amyotrophic lateral sclerosis: The protocol for a prospective, multicenter study. PLoS One. 2024; 19(5):e0303053. PMID: 38776297; PMCID: PMC11111088.
      Citations:    Fields:    Translation:HumansCells
    10. Barkmeier AJ, Herrin J, Swarna KS, Deng Y, Polley EC, Umpierrez GE, Galindo RJ, Ross JS, Mickelson MM, McCoy RG. Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, Dipeptidyl Peptidase-4 Inhibitors, and Sulfonylureas for Sight-Threatening Diabetic Retinopathy. Ophthalmol Retina. 2024 Oct; 8(10):943-952. PMID: 38735641.
      Citations:    Fields:    Translation:Humans
    11. Nogueira RG, Pinheiro A, Brinjikji W, Abbasi M, Al-Bayati AR, Mohammaden MH, Souza Viana L, Ferreira F, Abdelhamid H, Bhatt NR, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Arturo Larco JL, Fitzgerald S, Mereuta OM, Doyle K, Savastano LE, Cloft HJ, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Polley EC, Frankel MR, Kallmes DF, Haussen DC. Clot composition and recanalization outcomes in mechanical thrombectomy. J Neurointerv Surg. 2024 Apr 23; 16(5):466-470. PMID: 37419694.
      Citations:    Fields:    Translation:Humans
    12. McCoy RG, Herrin J, Swarna KS, Deng Y, Kent DM, Ross JS, Umpierrez GE, Galindo RJ, Crown WH, Borah BJ, Montori VM, Brito JP, Neumiller JJ, Mickelson MM, Polley EC. Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk. Nat Cardiovasc Res. 2024 Apr; 3(4):431-440. PMID: 38846711; PMCID: PMC11156225.
      Citations:    
    13. Hu C, Huang H, Na J, Lumby C, Abozaid M, Holdren MA, Rao TJ, Karam R, Pesaran T, Weyandt JD, Csuy CM, Seelaus CA, Young CC, Fulk K, Heidari Z, Morais Lyra PC, Couch RE, Persons B, Polley EC, Gnanaolivu RD, Boddicker NJ, Monteiro ANA, Yadav S, Domchek SM, Richardson ME, Couch FJ. Functional analysis and clinical classification of 462 germline BRCA2 missense variants affecting the DNA binding domain. Am J Hum Genet. 2024 03 07; 111(3):584-593. PMID: 38417439; PMCID: PMC10940015.
      Citations: 2     Fields:    Translation:HumansCells
    14. McCoy RG, Swarna KS, Deng Y, Herrin JS, Ross JS, Kent DM, Borah BJ, Crown WH, Montori VM, Umpierrez GE, Galindo RJ, Brito JP, Mickelson MM, Polley EC. Derivation of an Annualized Claims-Based Major Adverse Cardiovascular Event Estimator in Type 2 Diabetes. JACC Adv. 2024 Apr; 3(4):100852. PMID: 38939660; PMCID: PMC11198625.
      Citations:    
    15. Golembiewski EH, Garcia Bautista AE, Polley E, Umpierrez GE, Galindo RJ, Brito JP, Montori VM, Gockerman JP, Tesulov M, Labatte B, Mickelson MM, McCoy RG. Outcomes and Attributes Patients Value When Choosing Glucose-Lowering Medications: A Mixed-Methods Study. Clin Diabetes. 2024; 42(3):371-387. PMID: 39015157; PMCID: PMC11247043.
      Citations:    
    16. Morris J, Kunkel MW, White SL, Wishka DG, Lopez OD, Bowles L, Sellers Brady P, Ramsey P, Grams J, Rohrer T, Martin K, Dexheimer TS, Coussens NP, Evans D, Risbood P, Sonkin D, Williams JD, Polley EC, Collins JM, Doroshow JH, Teicher BA. Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems-based Resource. Mol Cancer Ther. 2023 Nov 01; 22(11):1270-1279. PMID: 37550087; PMCID: PMC10618733.
      Citations: 4     Fields:    Translation:HumansCells
    17. Didier NA, King AC, Polley EC, Fridberg DJ. Signal processing and machine learning with transdermal alcohol concentration to predict natural environment alcohol consumption. Exp Clin Psychopharmacol. 2024 Apr; 32(2):245-254. PMID: 37824232; PMCID: PMC10984798.
      Citations: 2     Fields:    Translation:Humans
    18. Jain RK, Weiner M, Polley E, Iwamaye A, Huang E, Vokes T. Electronic Health Records (EHRs) Can Identify Patients at High Risk of Fracture but Require Substantial Race Adjustments to Currently Available Fracture Risk Calculators. J Gen Intern Med. 2023 Dec; 38(16):3451-3459. PMID: 37715097; PMCID: PMC10713897.
      Citations: 2     Fields:    Translation:Humans
    19. Wallach JD, Deng Y, Polley EC, Dhruva SS, Herrin J, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Jeffery MM, Lyon TD, Ross JS, McCoy RG. Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials. Clin Trials. 2023 12; 20(6):689-698. PMID: 37589143; PMCID: PMC10843567.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    20. Deng Y, Polley EC, Wallach JD, Herrin J, Ross JS, McCoy RG. Comparative effectiveness of second line glucose lowering drug treatments using real world data: emulation of a target trial. BMJ Med. 2023; 2(1):e000419. PMID: 37577025; PMCID: PMC10414064.
      Citations: 2     
    21. Hu C, Nagaraj AB, Shimelis H, Montalban G, Lee KY, Huang H, Lumby CA, Na J, Susswein LR, Roberts ME, Marshall ML, Hiraki S, LaDuca H, Chao E, Yussuf A, Pesaran T, Neuhausen SL, Haiman CA, Kraft P, Lindstrom S, Palmer JR, Teras LR, Vachon CM, Yao S, Ong I, Nathanson KL, Weitzel JN, Boddicker N, Gnanaolivu R, Polley EC, Mer G, Cui G, Karam R, Richardson ME, Domchek SM, Yadav S, Hruska KS, Dolinsky J, Weroha SJ, Hart SN, Simard J, Masson JY, Pang YP, Couch FJ. Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C. Cancer Res. 2023 08 01; 83(15):2557-2571. PMID: 37253112; PMCID: PMC10390864.
      Citations: 3     Fields:    Translation:Humans
    22. Issa NP, Aydin S, Bhatnagar S, Baumgartner NW, Hill J, Aluri S, Valentic CS, Polley E, Gomez CM, Rezania K. Intermuscular Coherence in Spinocerebellar Ataxias 3 and 6: a Preliminary Study. Cerebellum. 2024 Apr; 23(2):601-608. PMID: 37428409; PMCID: PMC10776817.
      Citations: 2     Fields:    Translation:Humans
    23. Morra A, Schreurs MAC, Andrulis IL, Anton-Culver H, Augustinsson A, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brauch H, Broeks A, Buys SS, Camp NJ, Castelao JE, Cessna MH, Chang-Claude J, Chung WK, NBCS Collaborators, Colonna SV, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Dennis J, Devilee P, Dörk T, Dunning AM, Dwek M, Easton DF, Eccles DM, Eriksson M, Evans DG, Fasching PA, Fehm TN, Figueroa JD, Flyger H, Gabrielson M, Gago-Dominguez M, García-Closas M, García-Sáenz JA, Genkinger J, Grassmann F, Gündert M, Hahnen E, Haiman CA, Hamann U, Harrington PA, Hartikainen JM, Hoppe R, Hopper JL, Houlston RS, Howell A, ABCTB Investigators, kConFab Investigators, Jakubowska A, Janni W, Jernström H, John EM, Johnson N, Jones ME, Kristensen VN, Kurian AW, Lambrechts D, Le Marchand L, Lindblom A, Lubinski J, Lux MP, Mannermaa A, Mavroudis D, Mulligan AM, Muranen TA, Nevanlinna H, Nevelsteen I, Neven P, Newman WG, Obi N, Offit K, Olshan AF, Park-Simon TW, Patel AV, Peterlongo P, Phillips KA, Plaseska-Karanfilska D, Polley EC, Presneau N, Pylkäs K, Rack B, Radice P, Rashid MU, Rhenius V, Robson M, Romero A, Saloustros E, Sawyer EJ, Schmutzler RK, Schuetze S, Scott C, Shah M, Smichkoska S, Southey MC, Tapper WJ, Teras LR, Tollenaar RAEM, Tomczyk K, Tomlinson I, Troester MA, Vachon CM, van Veen EM, Wang Q, Wendt C, Wildiers H, Winqvist R, Ziogas A, Hall P, Pharoah PDP, Adank MA, Hollestelle A, Schmidt MK, Hooning MJ. Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Cancer Med. 2023 08; 12(15):16142-16162. PMID: 37401034; PMCID: PMC10469654.
      Citations: 1     Fields:    Translation:Humans
    24. Ngufor C, Yao X, Inselman JW, Ross JS, Graham DJ, Lee JY, Siontis KC, Desai NR, Shah ND, Noseworthy PA, Dhruva SS, Polley E. Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method. Am Heart J. 2023 06; 260:124-140. PMID: 36893934; PMCID: PMC10615250.
      Citations: 2     Fields:    Translation:Humans
    25. Morra A, Schreurs MAC, Andrulis IL, Anton-Culver H, Augustinsson A, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brauch H, Broeks A, Buys SS, Camp NJ, Castelao JE, Cessna MH, Chang-Claude J, Chung WK, Collaborators N, Colonna SV, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Dennis J, Devilee P, Dunning AM, Dwek M, Easton DF, Eccles DM, Eriksson M, Evans DG, Fasching PA, Fehm TN, Figueroa JD, Flyger H, Gabrielson M, Gago-Dominguez M, Genkinger J, Grassmann F, Hahnen E, Haiman CA, Hamann U, Harrington PA, Hartikainen JM, Hoppe R, Hopper JL, Houlston RS, Howell A, Investigators A, Investigators K, Jakubowska A, Janni W, John EM, Johnson N, Jones ME, Kristensen VN, Kurian AW, Lambrechts D, Marchand LL, Lindblom A, Lubinski J, Lux MP, Mannermaa A, Mavroudis D, Mulligan AM, Muranen TA, Nevanlinna H, Nevelsteen I, Neven P, Newman WG, Obi N, Offit K, Olshan AF, Park-Simon TW, Patel AV, Peterlongo P, Phillips KA, Plaseska-Karanfilska D, Polley EC, Presneau N, Rack B, Radice P, Rashid MU, Rhenius V, Robson M, Romero A, Saloustros E, Sawyer EJ, Schmutzler RK, Schuetze S, Scott C, Shah M, Smichkoska S, Southey MC, Tapper WJ, Teras LR, Tollenaar RAEM, Tomczyk K, Tomlinson I, Troester MA, Vachon CM, van Veen EM, Wang Q, Wendt C, Wildiers H, Winqvist R, Ziogas A, Hall P, Pharoah PDP, Adank MA, Hollestelle A, Schmidt MK, Hooning MJ, Dörk T, García-Closas M, García-Sáenz JA, Gündert M, Jernström H, Pylkäs K. Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Res Sq. 2023 Feb 13. PMID: 36824750; PMCID: PMC9949248.
      Citations:    
    26. Yadav S, Boddicker NJ, Na J, Polley EC, Hu C, Hart SN, Gnanaolivu RD, Larson N, Holtegaard S, Huang H, Dunn CA, Teras LR, Patel AV, Lacey JV, Neuhausen SL, Martinez E, Haiman C, Chen F, Ruddy KJ, Olson JE, John EM, Kurian AW, Sandler DP, O'Brien KM, Taylor JA, Weinberg CR, Anton-Culver H, Ziogas A, Zirpoli G, Goldgar DE, Palmer JR, Domchek SM, Weitzel JN, Nathanson KL, Kraft P, Couch FJ. Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2. J Clin Oncol. 2023 03 20; 41(9):1703-1713. PMID: 36623243; PMCID: PMC10022863.
      Citations: 29     Fields:    Translation:Humans
    27. Deng Y, Polley EC, Wallach JD, Dhruva SS, Herrin J, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Lyon TD, Shah ND, Ross JS, McCoy RG. Emulating the GRADE trial using real world data: retrospective comparative effectiveness study. BMJ. 2022 10 03; 379:e070717. PMID: 36191949; PMCID: PMC9527635.
      Citations: 9     Fields:    Translation:Humans
    28. Hu C, Susswein LR, Roberts ME, Yang H, Marshall ML, Hiraki S, Berkofsky-Fessler W, Gupta S, Shen W, Dunn CA, Huang H, Na J, Domchek SM, Yadav S, Monteiro ANA, Polley EC, Hart SN, Hruska KS, Couch FJ. Classification of BRCA2 Variants of Uncertain Significance (VUS) Using an ACMG/AMP Model Incorporating a Homology-Directed Repair (HDR) Functional Assay. Clin Cancer Res. 2022 09 01; 28(17):3742-3751. PMID: 35736817; PMCID: PMC9433957.
      Citations: 4     Fields:    Translation:Humans
    29. Olson EM, Falde SD, Wegehaupt AK, Polley E, Halvorsen AJ, Lawson DK, Ratelle JT. Dismissal disagreement and discharge delays: Associations of patient-clinician plan of care agreement with discharge outcomes. J Hosp Med. 2022 09; 17(9):710-718. PMID: 35942985.
      Citations:    Fields:    Translation:Humans
    30. Iversen ES, Lipton G, Hart SN, Lee KY, Hu C, Polley EC, Pesaran T, Yussuf A, LaDuca H, Chao E, Karam R, Goldgar DE, Couch FJ, Monteiro ANA. An integrative model for the comprehensive classification of BRCA1 and BRCA2 variants of uncertain clinical significance. NPJ Genom Med. 2022 Jun 03; 7(1):35. PMID: 35665744; PMCID: PMC9166814.
      Citations: 4     
    31. Ternifi R, Wang Y, Gu J, Polley EC, Carter JM, Pruthi S, Boughey JC, Fazzio RT, Fatemi M, Alizad A. Ultrasound high-definition microvasculature imaging with novel quantitative biomarkers improves breast cancer detection accuracy. Eur Radiol. 2022 Nov; 32(11):7448-7462. PMID: 35486168; PMCID: PMC9616967.
      Citations: 10     Fields:    Translation:Humans
    32. Lowry KP, Geuzinge HA, Stout NK, Alagoz O, Hampton J, Kerlikowske K, de Koning HJ, Miglioretti DL, van Ravesteyn NT, Schechter C, Sprague BL, Tosteson ANA, Trentham-Dietz A, Weaver D, Yaffe MJ, Yeh JM, Couch FJ, Hu C, Kraft P, Polley EC, Mandelblatt JS, Kurian AW, Robson ME, Breast Working Group of the Cancer Intervention and Surveillance Modeling Network (CISNET), in colla. Breast Cancer Screening Strategies for Women With ATM, CHEK2, and PALB2 Pathogenic Variants: A Comparative Modeling Analysis. JAMA Oncol. 2022 04 01; 8(4):587-596. PMID: 35175286; PMCID: PMC8855312.
      Citations: 22     Fields:    Translation:HumansPHPublic Health
    33. Jo JH, Harkins CP, Schwardt NH, Portillo JA, NISC Comparative Sequencing Program, Zimmerman MD, Carter CL, Hossen MA, Peer CJ, Polley EC, Figg WD, Moutsopoulos NM, Segre JA, Kong HH, Dartois V. Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics. Sci Transl Med. 2021 12 22; 13(625):eabd8077. PMID: 34936382; PMCID: PMC8878148.
      Citations: 30     Fields:    Translation:Humans
    34. Ternifi R, Wang Y, Polley EC, Fazzio RT, Fatemi M, Alizad A. Quantitative Biomarkers for Cancer Detection Using Contrast-Free Ultrasound High-Definition Microvessel Imaging: Fractal Dimension, Murray's Deviation, Bifurcation Angle & Spatial Vascularity Pattern. IEEE Trans Med Imaging. 2021 12; 40(12):3891-3900. PMID: 34329160; PMCID: PMC8668387.
      Citations: 11     Fields:    Translation:Humans
    35. Yadav S, Hu C, Nathanson KL, Weitzel JN, Goldgar DE, Kraft P, Gnanaolivu RD, Na J, Huang H, Boddicker NJ, Larson N, Gao C, Yao S, Weinberg C, Vachon CM, Trentham-Dietz A, Taylor JA, Sandler DR, Patel A, Palmer JR, Olson JE, Neuhausen S, Martinez E, Lindstrom S, Lacey JV, Kurian AW, John EM, Haiman C, Bernstein L, Auer PW, Anton-Culver H, Ambrosone CB, Karam R, Chao E, Yussuf A, Pesaran T, Dolinsky JS, Hart SN, LaDuca H, Polley EC, Domchek SM, Couch FJ. Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast. J Clin Oncol. 2021 12 10; 39(35):3918-3926. PMID: 34672684; PMCID: PMC8660003.
      Citations: 16     Fields:    Translation:Humans
    36. Wallach JD, Deng Y, McCoy RG, Dhruva SS, Herrin J, Berkowitz A, Polley EC, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Shah ND, Ross JS, Lyon TD. Real-world Cardiovascular Outcomes Associated With Degarelix vs Leuprolide for Prostate Cancer Treatment. JAMA Netw Open. 2021 10 01; 4(10):e2130587. PMID: 34677594; PMCID: PMC8536955.
      Citations: 13     Fields:    Translation:Humans
    37. LaDuca H, Niguidula N, Gutierrez S, Yussuf A, Davis BT, Chao EC, Pesaran T, Goldgar DE, Dolinsky JS, Yadav S, Polley EC, Hu C, Shimelis H, Lilyquist J, Na J, Lee KY, Hart SN, Couch FJ. Racial and Ethnic Differences in Multigene Hereditary Cancer Panel Test Results for Women With Breast Cancer. J Natl Cancer Inst. 2021 10 01; 113(10):1429-1433. PMID: 33146377; PMCID: PMC8633452.
      Citations: 13     Fields:    Translation:Humans
    38. Boddicker NJ, Hu C, Weitzel JN, Kraft P, Nathanson KL, Goldgar DE, Na J, Huang H, Gnanaolivu RD, Larson N, Yussuf A, Yao S, Vachon CM, Trentham-Dietz A, Teras L, Taylor JA, Scott CE, Sandler DP, Pesaran T, Patel AV, Palmer JR, Ong IM, Olson JE, O'Brien K, Neuhausen S, Martinez E, Ma H, Lindstrom S, Le Marchand L, Kooperberg C, Karam R, Hunter DJ, Hodge JM, Haiman C, Gaudet MM, Gao C, LaDuca H, Lacey JV, Dolinsky JS, Chao E, Carter BD, Burnside ES, Bertrand KA, Bernstein L, Auer PW, Ambrosone C, Yadav S, Hart SN, Polley EC, Domchek SM, Couch FJ. Risk of Late-Onset Breast Cancer in Genetically Predisposed Women. J Clin Oncol. 2021 11 01; 39(31):3430-3440. PMID: 34292776; PMCID: PMC8547938.
      Citations: 12     Fields:    Translation:Humans
    39. Domchek SM, Yao S, Chen F, Hu C, Hart SN, Goldgar DE, Nathanson KL, Ambrosone CB, Haiman CA, Couch FJ, Polley EC, Palmer JR, CARRIERS Consortium. Comparison of the Prevalence of Pathogenic Variants in Cancer Susceptibility Genes in Black Women and Non-Hispanic White Women With Breast Cancer in the United States. JAMA Oncol. 2021 Jul 01; 7(7):1045-1050. PMID: 34042955; PMCID: PMC8160931.
      Citations: 13     Fields:    Translation:Humans
    40. Zhang X, Kunz HE, Gries K, Hart CR, Polley EC, Lanza IR. Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing. J Physiol. 2021 07; 599(14):3581-3592. PMID: 34032280; PMCID: PMC8284426.
      Citations: 10     Fields:    Translation:Humans
    41. Gao C, Polley EC, Hart SN, Huang H, Hu C, Gnanaolivu R, Lilyquist J, Boddicker NJ, Na J, Ambrosone CB, Auer PL, Bernstein L, Burnside ES, Eliassen AH, Gaudet MM, Haiman C, Hunter DJ, Jacobs EJ, John EM, Ma H, Neuhausen SL, Newcomb PA, O'Brien KM, Olson JE, Ong IM, Patel AV, Palmer JR, Sandler DP, Tamimi R, Taylor JA, Teras LR, Trentham-Dietz A, Vachon CM, Weinberg CR, Yao S, Weitzel JN, Goldgar DE, Domchek SM, Nathanson KL, Couch FJ, Kraft P, Lindström S. Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score. J Clin Oncol. 2021 08 10; 39(23):2564-2573. PMID: 34101481; PMCID: PMC8330969.
      Citations: 27     Fields:    Translation:Humans
    42. Josephs KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, Botha H, Martin PR, Pham NTT, Stierwalt J, Ali F, Buciuc M, Baker M, Fernandez De Castro CH, Spychalla AJ, Schwarz CG, Reid RI, Senjem ML, Jack CR, Lowe VJ, Bigio EH, Reichard RR, Polley EJ, Ertekin-Taner N, Rademakers R, DeTure MA, Ross OA, Dickson DW, Whitwell JL. A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech. Nat Commun. 2021 06 08; 12(1):3452. PMID: 34103532; PMCID: PMC8187627.
      Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
    43. Kunz HE, Hart CR, Gries KJ, Parvizi M, Laurenti M, Dalla Man C, Moore N, Zhang X, Ryan Z, Polley EC, Jensen MD, Vella A, Lanza IR. Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E105-E121. PMID: 33998291; PMCID: PMC8321823.
      Citations: 41     Fields:    Translation:HumansCells
    44. Coignard J, Lush M, Beesley J, O'Mara TA, Dennis J, Tyrer JP, Barnes DR, McGuffog L, Leslie G, Bolla MK, Adank MA, Agata S, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Arnold N, Aronson KJ, Arun BK, Augustinsson A, Azzollini J, Barrowdale D, Baynes C, Becher H, Bermisheva M, Bernstein L, Bialkowska K, Blomqvist C, Bojesen SE, Bonanni B, Brauch H, Brenner H, Burwinkel B, Buys SS, Caligo MA, Campa D, Carter BD, Castelao JE, Chang-Claude J, Chanock SJ, Chung WK, Claes KBM, Clarke CL, GEMO Study Collaborators, EMBRACE Collaborators, Conroy DM, Czene K, Daly MB, Devilee P, Diez O, Ding YC, Domchek SM, Dos-Santos-Silva I, Dunning AM, Dwek M, Eccles DM, Eliassen AH, Engel C, Eriksson M, Evans DG, Fasching PA, Flyger H, Friedman E, Fritschi L, Frost D, Gapstur SM, Garber J, Gaudet MM, Gayther SA, Georgoulias V, Giles GG, Godwin AK, Goldgar DE, Greene MH, Haeberle L, Hahnen E, Haiman CA, Hall P, Hamann U, Harrington PA, Hart SN, He W, Hogervorst FBL, Hollestelle A, Hopper JL, Horcasitas DJ, Hulick PJ, Hunter DJ, Imyanitov EN, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Jager A, Jakubowska A, James PA, Jensen UB, John EM, Jones ME, Kaaks R, Kapoor PM, Karlan BY, Khusnutdinova E, Kiiski JI, Ko YD, Kosma VM, Kraft P, Kurian AW, Laitman Y, Lambrechts D, Le Marchand L, Lester J, Lesueur F, Lindstrom T, Loud JT, Luccarini C, Mannermaa A, Manoukian S, Martens JWM, Mebirouk N, Meindl A, Miller A, Milne RL, Montagna M, Nathanson KL, Neuhausen SL, Nevanlinna H, Nielsen FC, O'Brien KM, Olopade OI, Olson JE, Osorio A, Ottini L, Park-Simon TW, Parsons MT, Pedersen IS, Peshkin B, Peterlongo P, Peto J, Pharoah PDP, Phillips KA, Polley EC, Poppe B, Presneau N, Pujana MA, Punie K, Radice P, Rantala J, Rashid MU, Rennert G, Rennert HS, Robson M, Romero A, Rossing M, Saloustros E, Sandler DP, Santella R, Scheuner MT, Schmidt G, Scott C, Sharma P, Southey MC, Spinelli JJ, Steinsnyder Z, Stone J, Swerdlow A, Tamimi RM, Tapper WJ, Taylor JA, Terry MB, Thull DL, Toland AE, Torres D, Trainer AH, Tung N, Vachon CM, Vijai J, Wang Q, Wappenschmidt B, Weinberg CR, Weitzel JN, Wolk A, Yadav S, Yang XR, Zheng W, Ziogas A, Zorn KK, Park SK, Thomassen M, Offit K, Schmutzler RK, Couch FJ, Simard J, Chenevix-Trench G, Easton DF, Andrieu N, Antoniou AC, Aittomäki K, Borg A, Caldés T, Collée JM, Dörk T, Fostira F, Gago-Dominguez M, Garcia-Barberan V, García-Closas M, García-Sáenz JA, Gehrig A, Goldberg MS, González-Neira A, Guénel P, Håkansson N, Keeman R, Lopez-Fernández A, Margolin S, Olsson H, Schmidt MK, Soucy P, Stoppa-Lyonnet D, Teulé A, Tischkowitz M, Truong T, Vega A, Wendt C, Yannoukakos D. Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. Nat Commun. 2021 May 14; 12(1):2986. PMID: 33990587; PMCID: PMC8121813.
      Citations:    Fields:    
    45. Gu J, Polley EC, Boughey JC, Fazzio RT, Fatemi M, Alizad A. Prediction of Invasive Breast Cancer Using Mass Characteristic Frequency and Elasticity in Correlation with Prognostic Histologic Features and Immunohistochemical Biomarkers. Ultrasound Med Biol. 2021 08; 47(8):2193-2201. PMID: 33994231; PMCID: PMC8243825.
      Citations: 5     Fields:    Translation:Humans
    46. Gu J, Polley EC, Denis M, Carter JM, Pruthi S, Gregory AV, Boughey JC, Fazzio RT, Fatemi M, Alizad A. Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer. Breast Cancer Res. 2021 04 29; 23(1):52. PMID: 33926522; PMCID: PMC8082810.
      Citations: 13     Fields:    Translation:Humans
    47. Seyedsaadat SM, Neuhaus AA, Nicholson PJ, Polley EC, Hilditch CA, Mihal DC, Krings T, Benson JC, Mark I, Kallmes DF, Brinjikji W, Schaafsma JD. Differential Contribution of ASPECTS Regions to Clinical Outcome after Thrombectomy for Acute Ischemic Stroke. AJNR Am J Neuroradiol. 2021 06; 42(6):1104-1108. PMID: 33926898; PMCID: PMC8191662.
      Citations: 8     Fields:    Translation:Humans
    48. Ratelle JT, Herberts M, Miller D, Kumbamu A, Lawson D, Polley E, Beckman TJ. Relationships Between Time-at-Bedside During Hospital Ward Rounds, Clinician-Patient Agreement, and Patient Experience. J Patient Exp. 2021; 8:23743735211008303. PMID: 34179432; PMCID: PMC8205390.
      Citations: 2     
    49. Fasching PA, Yadav S, Hu C, Wunderle M, Hart SN, Polley EC, Lee KY, Gnanaolivu RD, Hadji P, Tesch H, Ettl J, Overkamp F, Ekici AB, Volz B, Uhrig S, Wallwiener M, Untch M, Kolberg HC, Beckmann MW, Hartmann A, Janni W, Wimberger P, Taran FA, Wallwiener D, Brucker SY, Schneeweiss A, Hartkopf AD, Couch FJ, Häberle L, Rübner M, Hübner H, Lux MP, Lüftner D, Müller V, Belleville E, Reis A, Fehm TN. Mutations in BRCA1/2 and Other Panel Genes in Patients With Metastatic Breast Cancer -Association With Patient and Disease Characteristics and Effect on Prognosis. J Clin Oncol. 2021 05 20; 39(15):1619-1630. PMID: 33780288; PMCID: PMC8274805.
      Citations: 25     Fields:    Translation:Humans
    50. Panda A, Korfiatis P, Suman G, Garg SK, Polley EC, Singh DP, Chari ST, Goenka AH. Two-stage deep learning model for fully automated pancreas segmentation on computed tomography: Comparison with intra-reader and inter-reader reliability at full and reduced radiation dose on an external dataset. Med Phys. 2021 May; 48(5):2468-2481. PMID: 33595105.
      Citations: 10     Fields:    Translation:Humans
    51. Brinjikji W, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Abbasi M, Dai D, Kadirvel R, Savastano L, Cloft HJ, Haussen DC, Al-Bayati AR, Mohammaden MH, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Polley EC, Kallmes DF, Fitzgerald S, Mereuta OM, Doyle K. Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology. J Neurointerv Surg. 2021 Jul; 13(7):594-598. PMID: 33722963; PMCID: PMC9069417.
      Citations: 20     Fields:    Translation:HumansCells
    52. Kapoor PM, Mavaddat N, Choudhury PP, Wilcox AN, Behrens S, Michailidou K, Dennis J, Bolla MK, Wang Q, Jung A, Abu-Ful Z, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Freeman LEB, Becher H, Beckmann MW, Beeghly-Fadiel A, Bernstein L, Bojesen SE, Brauch H, Brenner H, Cai Q, Campa D, Canzian F, Carter BD, Castelao JE, Chanock SJ, Chatterjee N, Chenevix-Trench G, Clarke CL, Couch FJ, Cox A, Cross SS, Czene K, Dai JY, Earp HS, Ekici AB, Eliassen AH, Eriksson M, Evans DG, Fasching PA, Figueroa J, Fritschi L, Gabrielson M, Gao C, Gapstur SM, Gaudet MM, Giles GG, Haeberle L, Haiman CA, Hall P, Hamann U, Hatse S, Heyworth J, Hoover RN, Hopper JL, Howell A, Hunter DJ, ABCTB Investigators, kConFab/AOCS Investigators, John EM, Jones ME, Kaaks R, Keeman R, Kitahara CM, Ko YD, Koutros S, Kurian AW, Lambrechts D, Le Marchand L, Lee E, Lejbkowicz F, Linet M, Lissowska J, Llaneza A, MacInnis RJ, Martinez ME, Maurer T, McLean C, Neuhausen SL, Newman WG, Norman A, O'Brien KM, Olshan AF, Olson JE, Orr N, Perou CM, Pita G, Polley EC, Prentice RL, Rennert G, Rennert HS, Ruddy KJ, Sandler DP, Saunders C, Schoemaker MJ, Schumacher F, Scott C, Scott RJ, Shu XO, Smeets A, Southey MC, Spinelli JJ, Stone J, Swerdlow AJ, Tamimi RM, Taylor JA, Troester MA, Vachon CM, van Veen EM, Wang X, Weinberg CR, Weltens C, Willett W, Winham SJ, Wolk A, Yang XR, Zheng W, Ziogas A, Dunning AM, Pharoah PDP, Schmidt MK, Kraft P, Easton DF, Milne RL, Chang-Claude J, Lindström S, Benitez J, Brüning T, Carracedo A, Gago-Dominguez M, González-Neira A, Guénel P, Håkansson N, Holleczek B, Olsson H, Schöttker B, García-Closas M. Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk. J Natl Cancer Inst. 2021 03 01; 113(3):329-337. PMID: 32359158; PMCID: PMC7936056.
      Citations: 27     Fields:    Translation:Humans
    53. Richardson ME, Hu C, Lee KY, LaDuca H, Fulk K, Durda KM, Deckman AM, Goldgar DE, Monteiro ANA, Gnanaolivu R, Hart SN, Polley EC, Chao E, Pesaran T, Couch FJ. Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance. Am J Hum Genet. 2021 03 04; 108(3):458-468. PMID: 33609447; PMCID: PMC8008494.
      Citations: 25     Fields:    Translation:HumansCells
    54. Coignard J, Lush M, Beesley J, O'Mara TA, Dennis J, Tyrer JP, Barnes DR, McGuffog L, Leslie G, Bolla MK, Adank MA, Agata S, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Arnold N, Aronson KJ, Arun BK, Augustinsson A, Azzollini J, Barrowdale D, Baynes C, Becher H, Bermisheva M, Bernstein L, Bialkowska K, Blomqvist C, Bojesen SE, Bonanni B, Brauch H, Brenner H, Burwinkel B, Buys SS, Caligo MA, Campa D, Carter BD, Castelao JE, Chang-Claude J, Chanock SJ, Chung WK, Claes KBM, Clarke CL, GEMO Study Collaborators, EMBRACE Collaborators, Conroy DM, Czene K, Daly MB, Devilee P, Diez O, Ding YC, Domchek SM, Dos-Santos-Silva I, Dunning AM, Dwek M, Eccles DM, Eliassen AH, Engel C, Eriksson M, Evans DG, Fasching PA, Flyger H, Friedman E, Fritschi L, Frost D, Gapstur SM, Garber J, Gaudet MM, Gayther SA, Georgoulias V, Giles GG, Godwin AK, Goldgar DE, Greene MH, Haeberle L, Hahnen E, Haiman CA, Hall P, Hamann U, Harrington PA, Hart SN, He W, Hogervorst FBL, Hollestelle A, Hopper JL, Horcasitas DJ, Hulick PJ, Hunter DJ, Imyanitov EN, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Jager A, Jakubowska A, James PA, Jensen UB, John EM, Jones ME, Kaaks R, Kapoor PM, Karlan BY, Khusnutdinova E, Kiiski JI, Ko YD, Kosma VM, Kraft P, Kurian AW, Laitman Y, Lambrechts D, Le Marchand L, Lester J, Lesueur F, Lindstrom T, Loud JT, Luccarini C, Mannermaa A, Manoukian S, Martens JWM, Mebirouk N, Meindl A, Miller A, Milne RL, Montagna M, Nathanson KL, Neuhausen SL, Nevanlinna H, Nielsen FC, O'Brien KM, Olopade OI, Olson JE, Osorio A, Ottini L, Park-Simon TW, Parsons MT, Pedersen IS, Peshkin B, Peterlongo P, Peto J, Pharoah PDP, Phillips KA, Polley EC, Poppe B, Presneau N, Pujana MA, Punie K, Radice P, Rantala J, Rashid MU, Rennert G, Rennert HS, Robson M, Romero A, Rossing M, Saloustros E, Sandler DP, Santella R, Scheuner MT, Schmidt G, Scott C, Sharma P, Southey MC, Spinelli JJ, Steinsnyder Z, Stone J, Swerdlow A, Tamimi RM, Tapper WJ, Taylor JA, Terry MB, Thull DL, Toland AE, Torres D, Trainer AH, Tung N, Vachon CM, Vijai J, Wang Q, Wappenschmidt B, Weinberg CR, Weitzel JN, Wolk A, Yadav S, Yang XR, Zheng W, Ziogas A, Zorn KK, Park SK, Thomassen M, Offit K, Schmutzler RK, Couch FJ, Simard J, Chenevix-Trench G, Easton DF, Andrieu N, Antoniou AC, Aittomäki K, Borg A, Caldés T, Collée JM, Dörk T, Fostira F, Gago-Dominguez M, Garcia-Barberan V, García-Closas M, García-Sáenz JA, Gehrig A, Goldberg MS, González-Neira A, Guénel P, Håkansson N, Keeman R, Lopez-Fernández A, Margolin S, Olsson H, Schmidt MK, Soucy P, Stoppa-Lyonnet D, Teulé A, Tischkowitz M, Truong T, Vega A, Wendt C, Yannoukakos D. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. Nat Commun. 2021 02 17; 12(1):1078. PMID: 33597508; PMCID: PMC7890067.
      Citations: 15     Fields:    Translation:Humans
    55. Hu C, Hart SN, Gnanaolivu R, Huang H, Lee KY, Na J, Gao C, Lilyquist J, Yadav S, Boddicker NJ, Samara R, Klebba J, Ambrosone CB, Anton-Culver H, Auer P, Bandera EV, Bernstein L, Bertrand KA, Burnside ES, Carter BD, Eliassen H, Gapstur SM, Gaudet M, Haiman C, Hodge JM, Hunter DJ, Jacobs EJ, John EM, Kooperberg C, Kurian AW, Le Marchand L, Lindstroem S, Lindstrom T, Ma H, Neuhausen S, Newcomb PA, O'Brien KM, Olson JE, Ong IM, Pal T, Palmer JR, Patel AV, Reid S, Rosenberg L, Sandler DP, Scott C, Tamimi R, Taylor JA, Trentham-Dietz A, Vachon CM, Weinberg C, Yao S, Ziogas A, Weitzel JN, Goldgar DE, Domchek SM, Nathanson KL, Kraft P, Polley EC, Couch FJ. A Population-Based Study of Genes Previously Implicated in Breast Cancer. N Engl J Med. 2021 02 04; 384(5):440-451. PMID: 33471974; PMCID: PMC8127622.
      Citations: 286     Fields:    Translation:Humans
    56. Chen AP, Kummar S, Moore N, Rubinstein LV, Zhao Y, Williams PM, Palmisano A, Sims D, O'Sullivan Coyne G, Rosenberger CL, Simpson M, Raghav KPS, Meric-Bernstam F, Leong S, Waqar S, Foster JC, Das B, Karlovich C, Lih CJ, Polley E, Simon R, Li MC, Piekarz R, Doroshow JH, Konaté MM. Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT): A Randomized Multicenter Phase II Trial. JCO Precis Oncol. 2021; 5. PMID: 33928209; PMCID: PMC8078898.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    57. Adusei SA, Gregory AV, Polley EC, Alizad A, Fatemi M. Does Body Position Affect Ultrasound Measurements of Bladder-Wall Elasticity? Ultrasound Med Biol. 2021 04; 47(4):1115-1119. PMID: 33446373; PMCID: PMC7897286.
      Citations: 1     Fields:    Translation:Humans
    58. Webb JM, Meixner DD, Adusei SA, Polley EC, Fatemi M, Alizad A. Automatic Deep Learning Semantic Segmentation of Ultrasound Thyroid Cineclips Using Recurrent Fully Convolutional Networks. IEEE Access. 2021; 9:5119-5127. PMID: 33747681; PMCID: PMC7978237.
      Citations: 8     
    59. Liu HC, Abbasi M, Ding YH, Polley EC, Kadirvel R, Kallmes DF, Brinjikji W, Urban MW, Fitzgerald S. Characterizing thrombus with multiple red blood cell compositions by optical coherence tomography attenuation coefficient. J Biophotonics. 2021 03; 14(3):e202000364. PMID: 33314731; PMCID: PMC8258800.
      Citations: 4     Fields:    Translation:HumansCells
    60. Palmer JR, Polley EC, Hu C, John EM, Haiman C, Hart SN, Gaudet M, Pal T, Anton-Culver H, Trentham-Dietz A, Bernstein L, Ambrosone CB, Bandera EV, Bertrand KA, Bethea TN, Gao C, Gnanaolivu RD, Huang H, Lee KY, LeMarchand L, Na J, Sandler DP, Shah PD, Yadav S, Yang W, Weitzel JN, Domchek SM, Goldgar DE, Nathanson KL, Kraft P, Yao S, Couch FJ. Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women. J Natl Cancer Inst. 2020 12 14; 112(12):1213-1221. PMID: 32427313; PMCID: PMC7735769.
      Citations: 38     Fields:    Translation:Humans
    61. Hu C, Polley EC, Yadav S, Lilyquist J, Shimelis H, Na J, Hart SN, Goldgar DE, Shah S, Pesaran T, Dolinsky JS, LaDuca H, Couch FJ. The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer From a Clinical Genetic Testing Cohort. J Natl Cancer Inst. 2020 12 14; 112(12):1231-1241. PMID: 32091585; PMCID: PMC7735776.
      Citations: 39     Fields:    Translation:Humans
    62. Gu J, Polley EC, Ternifi R, Nayak R, Boughey JC, Fazzio RT, Fatemi M, Alizad A. Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses. Breast. 2020 Dec; 54:248-255. PMID: 33188991; PMCID: PMC7670190.
      Citations: 4     Fields:    Translation:Humans
    63. Yadav S, Kasi PM, Bamlet WR, Ho TP, Polley EC, Hu C, Hart SN, Rabe KG, Boddicker NJ, Gnanaolivu RD, Lee KY, Lindstrom TH, Petersen GM, Couch FJ, McWilliams RR. Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic Adenocarcinoma. Clin Cancer Res. 2020 12 15; 26(24):6505-6512. PMID: 33028596; PMCID: PMC9063708.
      Citations: 13     Fields:    Translation:HumansCells
    64. Hart SN, Polley EC, Yussuf A, Yadav S, Goldgar DE, Hu C, LaDuca H, Smith LP, Fujimoto J, Li S, Couch FJ, Dolinsky JS. Mutation prevalence tables for hereditary cancer derived from multigene panel testing. Hum Mutat. 2020 08; 41(8):e1-e6. PMID: 32442341; PMCID: PMC7418063.
      Citations: 15     Fields:    Translation:Humans
    65. Hart SN, Polley EC, Shimelis H, Yadav S, Couch FJ. Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML. NPJ Breast Cancer. 2020; 6:13. PMID: 32377563; PMCID: PMC7190647.
      Citations: 17     
    66. Yadav S, Hu C, Hart SN, Boddicker N, Polley EC, Na J, Gnanaolivu R, Lee KY, Lindstrom T, Armasu S, Fitz-Gibbon P, Ghosh K, Stan DL, Pruthi S, Neal L, Sandhu N, Rhodes DJ, Klassen C, Peethambaram PP, Haddad TC, Olson JE, Hoskin TL, Goetz MP, Domchek SM, Boughey JC, Ruddy KJ, Couch FJ. Evaluation of Germline Genetic Testing Criteria in a Hospital-Based Series of Women With Breast Cancer. J Clin Oncol. 2020 05 01; 38(13):1409-1418. PMID: 32125938; PMCID: PMC7193748.
      Citations: 46     Fields:    Translation:Humans
    67. Golmakani MK, Polley EC. Super Learner for Survival Data Prediction. Int J Biostat. 2020 Feb 22. PMID: 32097120.
      Citations: 10     Fields:    
    68. Greathouse KL, White JR, Vargas AJ, Bliskovsky VV, Beck JA, von Muhlinen N, Polley EC, Bowman ED, Khan MA, Robles AI, Cooks T, Padgett N, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC, Ryan BM. Author Correction: Interaction between the microbiome and TP53 in human lung cancer. Genome Biol. 2020 Feb 20; 21(1):41. PMID: 32079537; PMCID: PMC7033853.
      Citations: 7     Fields:    
    69. Matejcic M, Patel Y, Lilyquist J, Hu C, Lee KY, Gnanaolivu RD, Hart SN, Polley EC, Yadav S, Boddicker NJ, Samara R, Xia L, Sheng X, Lubmawa A, Kiddu V, Masaba B, Namuguzi D, Mutema G, Job K, Henry DM, Ingles SA, Wilkens L, Le Marchand L, Watya S, Couch FJ, Conti DV, Haiman CA. Pathogenic Variants in Cancer Predisposition Genes and Prostate Cancer Risk in Men of African Ancestry. JCO Precis Oncol. 2020; 4:32-43. PMID: 32832836; PMCID: PMC7442213.
      Citations: 23     Fields:    
    70. Gregory A, Denis M, Bayat M, Kumar V, Kim BH, Webb J, Nayak R, Adabi S, Meixner DD, Polley EC, Fazzio RT, Fatemi M, Alizad A. Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation. PLoS One. 2020; 15(1):e0226994. PMID: 31929558; PMCID: PMC6957145.
      Citations: 3     Fields:    Translation:Humans
    71. Li H, LaDuca H, Pesaran T, Chao EC, Dolinsky JS, Parsons M, Spurdle AB, Polley EC, Shimelis H, Hart SN, Hu C, Couch FJ, Goldgar DE. Classification of variants of uncertain significance in BRCA1 and BRCA2 using personal and family history of cancer from individuals in a large hereditary cancer multigene panel testing cohort. Genet Med. 2020 04; 22(4):701-708. PMID: 31853058; PMCID: PMC7118020.
      Citations: 21     Fields:    Translation:Humans
    72. Choudhery S, Polley E, Conners AL. Assessment of MRI-detected lesions on screening tomosynthesis in patients with newly diagnosed breast cancer. Clin Imaging. 2020 Jan; 59(1):50-55. PMID: 31760277; PMCID: PMC6920563.
      Citations:    Fields:    Translation:Humans
    73. Yadav S, Hart SN, Hu C, Hillman D, Lee KY, Gnanaolivu R, Na J, Polley EC, Couch FJ, Kohli M. Contribution of Inherited DNA-Repair Gene Mutations to Hormone-Sensitive and Castrate-Resistant Metastatic Prostate Cancer and Implications for Clinical Outcome. JCO Precis Oncol. 2019; 3. PMID: 32923857; PMCID: PMC7446380.
      Citations: 9     Fields:    
    74. Paim AC, Cummins NW, Natesampillai S, Garcia-Rivera E, Kogan N, Neogi U, Sperk M, Bren GD, Deeks S, Polley E, Badley AD, Sönnerborg A. HIV elite control is associated with reduced TRAILshort expression. AIDS. 2019 09 01; 33(11):1757-1763. PMID: 31149947; PMCID: PMC6873462.
      Citations: 3     Fields:    Translation:HumansCells
    75. LaDuca H, Polley EC, Yussuf A, Hoang L, Gutierrez S, Hart SN, Yadav S, Hu C, Na J, Goldgar DE, Fulk K, Smith LP, Horton C, Profato J, Pesaran T, Gau CL, Pronold M, Davis BT, Chao EC, Couch FJ, Dolinsky JS. A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients. Genet Med. 2020 02; 22(2):407-415. PMID: 31406321; PMCID: PMC7000322.
      Citations: 85     Fields:    Translation:Humans
    76. Vachon CM, Scott CG, Tamimi RM, Thompson DJ, Fasching PA, Stone J, Southey MC, Winham S, Lilyquist J, Giles GG, Milne RL, MacInnis RJ, Baglietto L, Li J, Czene K, Bolla MK, Wang Q, Dennis J, Haeberle L, Eriksson M, Kraft P, Luben R, Wareham N, Olson JE, Norman A, Polley EC, Maskarinec G, Le Marchand L, Haiman CA, Hopper JL, Couch FJ, Easton DF, Hall P, Chatterjee N, Garcia-Closas M, Lindström S. Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk. Breast Cancer Res. 2019 05 22; 21(1):68. PMID: 31118087; PMCID: PMC6532188.
      Citations: 19     Fields:    Translation:Humans
    77. Liu Y, Chanana P, Davila JI, Hou X, Zanfagnin V, McGehee CD, Goode EL, Polley EC, Haluska P, Weroha SJ, Wang C. Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts. Sci Rep. 2019 04 19; 9(1):6314. PMID: 31004097; PMCID: PMC6474864.
      Citations: 27     Fields:    Translation:HumansAnimals
    78. Antwi SO, Fagan SE, Chaffee KG, Bamlet WR, Hu C, Polley EC, Hart SN, Shimelis H, Lilyquist J, Gnanaolivu RD, McWilliams RR, Oberg AL, Couch FJ, Petersen GM. Risk of Different Cancers Among First-degree Relatives of Pancreatic Cancer Patients: Influence of Probands' Susceptibility Gene Mutation Status. J Natl Cancer Inst. 2019 03 01; 111(3):264-271. PMID: 29982661; PMCID: PMC6410948.
      Citations: 7     Fields:    Translation:Humans
    79. Yang SX, Polley EC. Systemic treatment and radiotherapy, breast cancer subtypes, and survival after long-term clinical follow-up. Breast Cancer Res Treat. 2019 Jun; 175(2):287-295. PMID: 30746635; PMCID: PMC6533413.
      Citations: 14     Fields:    Translation:Humans
    80. Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Wang Q, Bolla MK, Yang X, Adank MA, Ahearn T, Allen J, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Barrdahl M, Beane Freeman LE, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Bogdanova NV, Bojesen SE, Bonanni B, Bremer M, Brenner H, Brentnall A, Brock IW, Brooks-Wilson A, Burwinkel B, Campa D, Carter BD, Castelao JE, Chanock SJ, Chlebowski R, Christiansen H, Clarke CL, Cordina-Duverger E, Cornelissen S, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dos-Santos-Silva I, Durcan L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Ellberg C, Engel C, Eriksson M, Evans DG, Fasching PA, Figueroa J, Fletcher O, Flyger H, Fritschi L, Gabrielson M, Gapstur SM, Gaudet MM, Georgoulias V, Giles GG, Gilyazova IR, Glendon G, Goldgar DE, Grip M, Gronwald J, Haeberle L, Hahnen E, Haiman CA, Hamann U, Hankinson SE, Harkness EF, Hart SN, He W, Hein A, Heyworth J, Hillemanns P, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Howell A, Huang G, Humphreys K, Hunter DJ, Jakimovska M, Jakubowska A, Janni W, John EM, Johnson N, Jones ME, Jukkola-Vuorinen A, Jung A, Kaaks R, Kaczmarek K, Keeman R, Kerin MJ, Khusnutdinova E, Kiiski JI, Knight JA, Ko YD, Kosma VM, Koutros S, Kristensen VN, Lambrechts D, Le Marchand L, Lee E, Lejbkowicz F, Lilyquist J, Lindblom A, Lissowska J, Loibl S, Long J, Lubinski J, Lux MP, MacInnis RJ, Maishman T, Makalic E, Maleva Kostovska I, Mannermaa A, Manoukian S, Martens JWM, Martinez ME, Mavroudis D, McLean C, Meindl A, Menon U, Middha P, Miller N, Mulligan AM, Neuhausen SL, Nevanlinna H, Neven P, Newman WG, Nielsen SF, Norman A, Offit K, Olson JE, Orr N, Pankratz VS, Park-Simon TW, Peterlongo P, Peto J, Pinchev M, Plaseska-Karanfilska D, Polley EC, Prentice R, Presneau N, Prokofyeva D, Purrington K, Rack B, Radice P, Rau-Murthy R, Rennert G, Rennert HS, Rhenius V, Robson M, Romero A, Ruddy KJ, Ruebner M, Saloustros E, Sandler DP, Sawyer EJ, Schmidt DF, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Schumacher F, Schwentner L, Scott C, Scott RJ, Seynaeve C, Shah M, Sherman ME, Shrubsole MJ, Shu XO, Slager S, Smeets A, Sohn C, Southey MC, Spinelli JJ, Stone J, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Terry MB, Tollenaar RAEM, Tomlinson I, Tzardi M, Ulmer HU, Untch M, Vachon CM, van Veen EM, Vijai J, Weinberg CR, Whittemore AS, Wildiers H, Willett W, Winqvist R, Wolk A, Yang XR, Yannoukakos D, Zhang Y, Zheng W, Ziogas A, ABCTB Investigators, kConFab/AOCS Investigators, Dunning AM, Thompson DJ, Chenevix-Trench G, Chang-Claude J, Schmidt MK, Milne RL, Pharoah PDP, Antoniou AC, Chatterjee N, Kraft P, Easton DF, Chen TH, Aittomäki K, Auvinen P, Blomqvist C, Børresen-Dale AL, Brauch H, Brucker SY, Brüning T, Collée JM, Dörk T, Dumont M, Försti A, Gago-Dominguez M, García-Sáenz JA, Goldberg MS, González-Neira A, Grenaker Alnæs GI, Grundy A, Guénel P, Håkansson N, Kataja V, Krüger U, Kühl T, Lindström S, Lo WY, Margolin S, Moreno F, Mulot C, Muñoz-Garzon VM, Nordestgaard BG, Olsson H, Perez JIA, Pérez-Barrios C, Pylkäs K, Schürmann P, Soucy P, Stegmaier C, Thöne K, Truong T, Wendt C, NBCS Collaborators, Hall P, García-Closas M, Simard J. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. Am J Hum Genet. 2019 01 03; 104(1):21-34. PMID: 30554720; PMCID: PMC6323553.
      Citations: 430     Fields:    Translation:Humans
    81. Long B, Lilyquist J, Weaver A, Hu C, Gnanaolivu R, Lee KY, Hart SN, Polley EC, Bakkum-Gamez JN, Couch FJ, Dowdy SC. Cancer susceptibility gene mutations in type I and II endometrial cancer. Gynecol Oncol. 2019 01; 152(1):20-25. PMID: 30612635; PMCID: PMC6326093.
      Citations: 21     Fields:    Translation:Humans
    82. Monks A, Zhao Y, Hose C, Hamed H, Krushkal J, Fang J, Sonkin D, Palmisano A, Polley EC, Fogli LK, Miller SB, Simpson MA, Voth AR, Li MC, Harris E, Wu X, Connelly JW, Rapisarda A, Teicher BA, Simon R, Doroshow JH, Konaté MM. The NCI Transcriptional Pharmacodynamics Workbench: A Tool to Examine Dynamic Expression Profiling of Therapeutic Response in the NCI-60 Cell Line Panel. Cancer Res. 2018 12 15; 78(24):6807-6817. PMID: 30355619; PMCID: PMC6295263.
      Citations: 34     Fields:    Translation:HumansCells
    83. Greathouse KL, White JR, Vargas AJ, Bliskovsky VV, Beck JA, von Muhlinen N, Polley EC, Bowman ED, Khan MA, Robles AI, Cooks T, Padgett N, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC, Ryan BM. Interaction between the microbiome and TP53 in human lung cancer. Genome Biol. 2018 08 24; 19(1):123. PMID: 30143034; PMCID: PMC6109311.
      Citations: 186     Fields:    Translation:HumansCells
    84. Shimelis H, LaDuca H, Hu C, Hart SN, Na J, Thomas A, Akinhanmi M, Moore RM, Brauch H, Cox A, Eccles DM, Ewart-Toland A, Fasching PA, Fostira F, Garber J, Godwin AK, Konstantopoulou I, Nevanlinna H, Sharma P, Yannoukakos D, Yao S, Feng BJ, Tippin Davis B, Lilyquist J, Pesaran T, Goldgar DE, Polley EC, Dolinsky JS, Couch FJ. Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing. J Natl Cancer Inst. 2018 08 01; 110(8):855-862. PMID: 30099541; PMCID: PMC6093350.
      Citations: 136     Fields:    Translation:Humans
    85. Hu C, LaDuca H, Shimelis H, Polley EC, Lilyquist J, Hart SN, Na J, Thomas A, Lee KY, Davis BT, Black MH, Pesaran T, Goldgar DE, Dolinsky JS, Couch FJ. Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes. JCO Precis Oncol. 2018; 2. PMID: 31497750; PMCID: PMC6731034.
      Citations: 23     Fields:    
    86. Hu C, Hart SN, Polley EC, Gnanaolivu R, Shimelis H, Lee KY, Lilyquist J, Na J, Moore R, Antwi SO, Bamlet WR, Chaffee KG, DiCarlo J, Wu Z, Samara R, Kasi PM, McWilliams RR, Petersen GM, Couch FJ. Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. JAMA. 2018 06 19; 319(23):2401-2409. PMID: 29922827; PMCID: PMC6092184.
      Citations: 214     Fields:    Translation:Humans
    87. Natesampillai S, Cummins NW, Nie Z, Sampath R, Baker JV, Henry K, Pinzone M, O'Doherty U, Polley EC, Bren GD, Katzmann DJ, Badley AD. HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome. J Virol. 2018 07 01; 92(13). PMID: 29643240; PMCID: PMC6002723.
      Citations: 13     Fields:    Translation:HumansCells
    88. Hart SN, Hoskin T, Shimelis H, Moore RM, Feng B, Thomas A, Lindor NM, Polley EC, Goldgar DE, Iversen E, Monteiro ANA, Suman VJ, Couch FJ. Comprehensive annotation of BRCA1 and BRCA2 missense variants by functionally validated sequence-based computational prediction models. Genet Med. 2019 01; 21(1):71-80. PMID: 29884841; PMCID: PMC6287763.
      Citations: 31     Fields:    Translation:Humans
    89. Glatz M, Jo JH, Kennedy EA, Polley EC, Segre JA, Simpson EL, Kong HH. Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis. PLoS One. 2018; 13(2):e0192443. PMID: 29489859; PMCID: PMC5830298.
      Citations: 43     Fields:    Translation:HumansCells
    90. Daniels LM, Sorita A, Kashiwagi DT, Okubo M, Small E, Polley EC, Sawatsky AP. Characterizing Potentially Preventable Admissions: A Mixed Methods Study of Rates, Associated Factors, Outcomes, and Physician Decision-Making. J Gen Intern Med. 2018 05; 33(5):737-744. PMID: 29340940; PMCID: PMC5910342.
      Citations: 10     Fields:    Translation:Humans
    91. Lilyquist J, LaDuca H, Polley E, Davis BT, Shimelis H, Hu C, Hart SN, Dolinsky JS, Couch FJ, Goldgar DE. Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls. Gynecol Oncol. 2017 11; 147(2):375-380. PMID: 28888541; PMCID: PMC5801741.
      Citations: 61     Fields:    Translation:Humans
    92. Couch FJ, Shimelis H, Hu C, Hart SN, Polley EC, Na J, Hallberg E, Moore R, Thomas A, Lilyquist J, Feng B, McFarland R, Pesaran T, Huether R, LaDuca H, Chao EC, Goldgar DE, Dolinsky JS. Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer. JAMA Oncol. 2017 Sep 01; 3(9):1190-1196. PMID: 28418444; PMCID: PMC5599323.
      Citations: 274     Fields:    Translation:Humans
    93. Palmisano A, Zhao Y, Li MC, Polley EC, Simon RM. OpenGeneMed: a portable, flexible and customizable informatics hub for the coordination of next-generation sequencing studies in support of precision medicine trials. Brief Bioinform. 2017 09 01; 18(5):723-734. PMID: 27422621.
      Citations: 2     Fields:    Translation:Humans
    94. Liu H, Antony S, Roy K, Juhasz A, Wu Y, Lu J, Meitzler JL, Jiang G, Polley E, Doroshow JH. Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells. Oncotarget. 2017 Jun 13; 8(24):38113-38135. PMID: 28498822; PMCID: PMC5503519.
      Citations: 26     Fields:    Translation:HumansCells
    95. Holbeck SL, Camalier R, Crowell JA, Govindharajulu JP, Hollingshead M, Anderson LW, Polley E, Rubinstein L, Srivastava A, Wilsker D, Collins JM, Doroshow JH. The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity. Cancer Res. 2017 07 01; 77(13):3564-3576. PMID: 28446463; PMCID: PMC5499996.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    96. Kummar S, O'Sullivan Coyne G, Do KT, Turkbey B, Meltzer PS, Polley E, Choyke PL, Meehan R, Vilimas R, Horneffer Y, Juwara L, Lih A, Choudhary A, Mitchell SA, Helman LJ, Doroshow JH, Chen AP. Clinical Activity of the ?-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis). J Clin Oncol. 2017 May 10; 35(14):1561-1569. PMID: 28350521; PMCID: PMC5455706.
      Citations: 80     Fields:    Translation:HumansCTClinical Trials
    97. Yang SX, Polley EC, Nguyen D. Association of ?H2AX at Diagnosis with Chemotherapy Outcome in Patients with Breast Cancer. Theranostics. 2017; 7(4):945-951. PMID: 28382166; PMCID: PMC5381256.
      Citations: 8     Fields:    Translation:Humans
    98. Lih CJ, Harrington RD, Sims DJ, Harper KN, Bouk CH, Datta V, Yau J, Singh RR, Routbort MJ, Luthra R, Patel KP, Mantha GS, Krishnamurthy S, Ronski K, Walther Z, Finberg KE, Canosa S, Robinson H, Raymond A, Le LP, McShane LM, Polley EC, Conley BA, Doroshow JH, Iafrate AJ, Sklar JL, Hamilton SR, Williams PM. Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial: Molecular Analysis for Therapy Choice Clinical Trial. J Mol Diagn. 2017 03; 19(2):313-327. PMID: 28188106; PMCID: PMC5397672.
      Citations: 78     Fields:    Translation:Humans
    99. Jo JH, Deming C, Kennedy EA, Conlan S, Polley EC, Ng WI, NISC Comparative Sequencing Program, Segre JA, Kong HH. Diverse Human Skin Fungal Communities in Children Converge in Adulthood. J Invest Dermatol. 2016 12; 136(12):2356-2363. PMID: 27476723; PMCID: PMC5687974.
      Citations: 60     Fields:    Translation:HumansAnimals
    100. Polley E, Kunkel M, Evans D, Silvers T, Delosh R, Laudeman J, Ogle C, Reinhart R, Selby M, Connelly J, Harris E, Fer N, Sonkin D, Kaur G, Monks A, Malik S, Morris J, Teicher BA. Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression. J Natl Cancer Inst. 2016 10; 108(10). PMID: 27247353; PMCID: PMC6279282.
      Citations: 82     Fields:    Translation:HumansCells
    101. Sims DJ, Harrington RD, Polley EC, Forbes TD, Mehaffey MG, McGregor PM, Camalier CE, Harper KN, Bouk CH, Das B, Conley BA, Doroshow JH, Williams PM, Lih CJ. Plasmid-Based Materials as Multiplex Quality Controls and Calibrators for Clinical Next-Generation Sequencing Assays. J Mol Diagn. 2016 05; 18(3):336-349. PMID: 27105923; PMCID: PMC4851732.
      Citations: 13     Fields:    Translation:Humans
    102. Goldstein BA, Polley EC, Briggs FB, van der Laan MJ, Hubbard A. Testing the Relative Performance of Data Adaptive Prediction Algorithms: A Generalized Test of Conditional Risk Differences. Int J Biostat. 2016 05 01; 12(1):117-29. PMID: 26529567; PMCID: PMC4854799.
      Citations: 2     Fields:    Translation:Humans
    103. Chang LC, Das B, Lih CJ, Si H, Camalier CE, McGregor PM, Polley E. RefCNV: Identification of Gene-Based Copy Number Variants Using Whole Exome Sequencing. Cancer Inform. 2016; 15:65-71. PMID: 27147817; PMCID: PMC4849420.
      Citations: 2     
    104. Yang SX, Polley E, Lipkowitz S. New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer. Cancer Treat Rev. 2016 Apr; 45:87-96. PMID: 26995633; PMCID: PMC7436195.
      Citations: 120     Fields:    Translation:HumansCells
    105. Kaur G, Reinhart RA, Monks A, Evans D, Morris J, Polley E, Teicher BA. Bromodomain and hedgehog pathway targets in small cell lung cancer. Cancer Lett. 2016 Feb 28; 371(2):225-39. PMID: 26683772; PMCID: PMC4738144.
      Citations: 28     Fields:    Translation:HumansCells
    106. Lih CJ, Sims DJ, Harrington RD, Polley EC, Zhao Y, Mehaffey MG, Forbes TD, Das B, Walsh WD, Datta V, Harper KN, Bouk CH, Rubinstein LV, Simon RM, Conley BA, Chen AP, Kummar S, Doroshow JH, Williams PM. Analytical Validation and Application of a Targeted Next-Generation Sequencing Mutation-Detection Assay for Use in Treatment Assignment in the NCI-MPACT Trial. J Mol Diagn. 2016 Jan; 18(1):51-67. PMID: 26602013; PMCID: PMC5812775.
      Citations: 23     Fields:    Translation:HumansCells
    107. Elkins JM, Fedele V, Szklarz M, Abdul Azeez KR, Salah E, Mikolajczyk J, Romanov S, Sepetov N, Huang XP, Roth BL, Al Haj Zen A, Fourches D, Muratov E, Tropsha A, Morris J, Teicher BA, Kunkel M, Polley E, Lackey KE, Atkinson FL, Overington JP, Bamborough P, Price DJ, Willson TM, Drewry DH, Knapp S, Zuercher WJ, Müller S. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan; 34(1):95-103. PMID: 26501955.
      Citations: 156     Fields:    Translation:Cells
    108. Teicher BA, Polley E, Kunkel M, Evans D, Silvers T, Delosh R, Laudeman J, Ogle C, Reinhart R, Selby M, Connelly J, Harris E, Monks A, Morris J. Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA Expression. Mol Cancer Ther. 2015 Nov; 14(11):2452-62. PMID: 26351324; PMCID: PMC4636476.
      Citations: 36     Fields:    Translation:HumansCells
    109. Do K, Speranza G, Chang LC, Polley EC, Bishop R, Zhu W, Trepel JB, Lee S, Lee MJ, Kinders RJ, Phillips L, Collins J, Lyons J, Jeong W, Antony R, Chen AP, Neckers L, Doroshow JH, Kummar S. Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors. Invest New Drugs. 2015 Aug; 33(4):921-30. PMID: 26082332; PMCID: PMC7709710.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    110. Zhao Y, Polley EC, Li MC, Lih CJ, Palmisano A, Sims DJ, Rubinstein LV, Conley BA, Chen AP, Williams PM, Kummar S, Doroshow JH, Simon RM. GeneMed: An Informatics Hub for the Coordination of Next-Generation Sequencing Studies that Support Precision Oncology Clinical Trials. Cancer Inform. 2015; 14(Suppl 2):45-55. PMID: 25861217; PMCID: PMC4368061.
      Citations: 13     
    111. Kummar S, Williams PM, Lih CJ, Polley EC, Chen AP, Rubinstein LV, Zhao Y, Simon RM, Conley BA, Doroshow JH. Application of molecular profiling in clinical trials for advanced metastatic cancers. J Natl Cancer Inst. 2015 Apr; 107(4). PMID: 25663694; PMCID: PMC4334817.
      Citations: 24     Fields:    Translation:HumansCells
    112. Polley MY, Polley EC, Huang EP, Freidlin B, Simon R. Two-stage adaptive cutoff design for building and validating a prognostic biomarker signature. Stat Med. 2014 Dec 20; 33(29):5097-110. PMID: 25263614; PMCID: PMC4227914.
      Citations: 4     Fields:    Translation:Humans
    113. Byakika-Tusiime J, Polley EC, Oyugi JH, Bangsberg DR. Free HIV antiretroviral therapy enhances adherence among individuals on stable treatment: implications for potential shortfalls in free antiretroviral therapy. PLoS One. 2013; 8(9):e70375. PMID: 24039704; PMCID: PMC3764136.
      Citations: 1     Fields:    Translation:Humans
    114. Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS. The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. Cancer Res. 2013 Jul 15; 73(14):4372-82. PMID: 23856246; PMCID: PMC4893961.
      Citations: 161     Fields:    Translation:HumansCells
    115. Simon R, Polley E. Clinical trials for precision oncology using next-generation sequencing. Per Med. 2013 Jul; 10(5):485-495. PMID: 29758837.
      Citations: 9     Fields:    
    116. Kummar S, Allen D, Monks A, Polley EC, Hose CD, Ivy SP, Turkbey IB, Lawrence S, Kinders RJ, Choyke P, Simon R, Steinberg SM, Doroshow JH, Helman L. Cediranib for metastatic alveolar soft part sarcoma. J Clin Oncol. 2013 Jun 20; 31(18):2296-302. PMID: 23630200; PMCID: PMC3677840.
      Citations: 81     Fields:    Translation:HumansCTClinical Trials
    117. Oh J, Conlan S, Polley EC, Segre JA, Kong HH. Shifts in human skin and nares microbiota of healthy children and adults. Genome Med. 2012; 4(10):77. PMID: 23050952; PMCID: PMC3580446.
      Citations: 158     Fields:    
    118. Kilpatrick RD, Gilbertson D, Brookhart MA, Polley E, Rothman KJ, Bradbury BD. Exploring large weight deletion and the ability to balance confounders when using inverse probability of treatment weighting in the presence of rare treatment decisions. Pharmacoepidemiol Drug Saf. 2013 Feb; 22(2):111-21. PMID: 22674782.
      Citations: 14     Fields:    Translation:Humans
    119. Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, NISC Comparative Sequence Program, Murray PR, Turner ML, Segre JA. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012 May; 22(5):850-9. PMID: 22310478; PMCID: PMC3337431.
      Citations: 669     Fields:    Translation:HumansCells
    120. Goldstein BA, Polley EC, Briggs FB. Random forests for genetic association studies. Stat Appl Genet Mol Biol. 2011; 10(1):32. PMID: 22889876; PMCID: PMC3154091.
      Citations: 77     Fields:    Translation:Humans
    121. Namiki T, Tanemura A, Valencia JC, Coelho SG, Passeron T, Kawaguchi M, Vieira WD, Ishikawa M, Nishijima W, Izumo T, Kaneko Y, Katayama I, Yamaguchi Y, Yin L, Polley EC, Liu H, Kawakami Y, Eishi Y, Takahashi E, Yokozeki H, Hearing VJ. AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6597-602. PMID: 21460252; PMCID: PMC3081019.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    122. van der Laan MJ, Polley EC, Hubbard AE. Super learner. Stat Appl Genet Mol Biol. 2007; 6:Article25. PMID: 17910531.
      Citations: 613     Fields:    
    123. Sinisi SE, Polley EC, Petersen ML, Rhee SY, van der Laan MJ. Super learning: an application to the prediction of HIV-1 drug resistance. Stat Appl Genet Mol Biol. 2007; 6:Article7. PMID: 17402922; PMCID: PMC2473869.
      Citations: 20     Fields:    Translation:Cells
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