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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
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Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 2011 Apr; 60(4):1168-76.
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PubMed
subject areas
Adipose Tissue
Animals
Blotting, Western
Bone Marrow Cells
Cells, Cultured
Dietary Fats
Fatty Liver
Female
Humans
Immunohistochemistry
Inflammation
Insulin Resistance
JNK Mitogen-Activated Protein Kinases
Liver
Macrophages
Male
MAP Kinase Kinase Kinases
Mice
Mice, Knockout
Obesity
Proto-Oncogene Proteins
Reverse Transcriptase Polymerase Chain Reaction
Triglycerides
authors with profiles
Eugene Chang