Multiple Endocrine Neoplasia Type 2a
"Multiple Endocrine Neoplasia Type 2a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
| Descriptor ID |
D018813
|
| MeSH Number(s) |
C04.588.322.400.505 C04.651.600.505 C04.700.630.505 C16.320.700.630.505 C19.344.400.505
|
| Concept/Terms |
Multiple Endocrine Neoplasia Type 2a- Multiple Endocrine Neoplasia Type 2a
- MEA II
- MEA IIa
- MEN 2
- MEN 2a
- MEN II
- MEN IIa
- MEN-2A Syndrome
- MEN 2A Syndrome
- MEN-2A Syndromes
- MEN2a
- Multiple Endocrine Neoplasia Type 2
- Multiple Endocrine Neoplasms Type 2a
- Neoplasia, Multiple Endocrine Type 2a
- Neoplasms, Multiple Endocrine Type 2a
- Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
- Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
- Sipple Syndrome
- Multiple Endocrine Neoplasia, Type IIa
- MEA 2a
|
Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 2a".
Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 2a".
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 2a" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 2a" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 2a" by people in Profiles.
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Management of the Parathyroid Glands During Preventive Thyroidectomy in Patients With Multiple Endocrine Neoplasia Type 2. Ann Surg. 2015 Oct; 262(4):641-6.
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Genetic screening of patients with medullary thyroid cancer in a referral center in Greece during the past two decades. Eur J Endocrinol. 2015 Apr; 172(4):501-9.
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Pheochromocytoma in an 8-year-old patient with multiple endocrine neoplasia type 2A: implications for screening. J Surg Oncol. 2013 Sep; 108(4):203-6.
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Sporadic and familial medullary thyroid carcinoma: state of the art. Surg Clin North Am. 2009 Oct; 89(5):1193-204.
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Proteomic profiling of von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 pheochromocytomas reveals different expression of chromogranin B. Endocr Relat Cancer. 2007 Jun; 14(2):463-71.
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Multiple endocrine neoplasia 2A syndrome presenting as peripartum cardiomyopathy due to catecholamine excess. Eur J Endocrinol. 2004 Dec; 151(6):771-7.
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Pheochromocytoma storm presenting as cardiovascular collapse at term pregnancy. Rev Cardiovasc Med. 2004; 5(4):226-30.
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Adrenal medullary calcitonin-like factor: a key to multiple endocrine neoplasia, type 2? Surgery. 1970 Jul; 68(1):146-9.