Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.

Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):678-89.

View in: PubMed

subject areas

Adult
Aged
Aged, 80 and over
Animals
Apoptosis
Dose-Response Relationship, Drug
Endothelium, Vascular
Female
Humans
Indoles
Male
Mice
Mice, Nude
Middle Aged
Neovascularization, Pathologic
Pancreatic Neoplasms
Phosphorylation
Propionates
Pyrroles
Receptor, Platelet-Derived Growth Factor beta
Transplantation, Heterologous
Vascular Endothelial Growth Factor Receptor-2