Ribonucleoprotein, U4-U6 Small Nuclear
"Ribonucleoprotein, U4-U6 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.
| Descriptor ID |
D017414
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| MeSH Number(s) |
D12.776.157.725.500.875.615 D12.776.664.962.500.875.615
|
| Concept/Terms |
Ribonucleoprotein, U4-U6 Small Nuclear- Ribonucleoprotein, U4-U6 Small Nuclear
- Ribonucleoprotein, U4 U6 Small Nuclear
- U4-U6 Small Nuclear Ribonucleoproteins
- U4 U6 Small Nuclear Ribonucleoproteins
- Small Nuclear Ribonucleoproteins, U4-U6
- Small Nuclear Ribonucleoproteins, U4 U6
- U4-U6 snRNP
- Ribonucleoproteins, Small, U4-U6
U6 snRNP- U6 snRNP
- U6 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U6 Small Nuclear
- Small Nuclear Ribonucleoproteins, U6
U4 snRNP- U4 snRNP
- U4 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U4 Small Nuclear
- Small Nuclear Ribonucleoproteins, U4
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Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U4-U6 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U4-U6 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U4-U6 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in Profiles.
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Structure of a spliceosome remodelled for exon ligation. Nature. 2017 02 16; 542(7641):377-380.
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Cryo-EM structure of the spliceosome immediately after branching. Nature. 2016 09 08; 537(7619):197-201.
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A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat Struct Mol Biol. 2013 Jun; 20(6):728-34.
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Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs. Am J Hum Genet. 2009 Nov; 85(5):617-27.
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A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol. 2008 May; 15(5):444-51.