Chromatin Immunoprecipitation
"Chromatin Immunoprecipitation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
| Descriptor ID |
D047369
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| MeSH Number(s) |
E05.393.170 E05.478.605.160
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chromatin Immunoprecipitation".
Below are MeSH descriptors whose meaning is more specific than "Chromatin Immunoprecipitation".
This graph shows the total number of publications written about "Chromatin Immunoprecipitation" by people in this website by year, and whether "Chromatin Immunoprecipitation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 8 | 8 |
| 2006 | 0 | 5 | 5 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 4 | 4 |
| 2010 | 1 | 11 | 12 |
| 2011 | 2 | 8 | 10 |
| 2012 | 3 | 8 | 11 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 7 | 7 |
| 2015 | 1 | 8 | 9 |
| 2016 | 0 | 8 | 8 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 3 | 3 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromatin Immunoprecipitation" by people in Profiles.
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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis. Nat Metab. 2024 Feb; 6(2):304-322.
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DeepG4: A deep learning approach to predict cell-type specific active G-quadruplex regions. PLoS Comput Biol. 2021 08; 17(8):e1009308.
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Sequence deeper without sequencing more: Bayesian resolution of ambiguously mapped reads. PLoS Comput Biol. 2021 04; 17(4):e1008926.
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Decoding the protein composition of whole nucleosomes with Nuc-MS. Nat Methods. 2021 03; 18(3):303-308.
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Native internally calibrated chromatin immunoprecipitation for quantitative studies of histone post-translational modifications. Nat Protoc. 2019 12; 14(12):3275-3302.
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Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies. Mol Cell. 2018 10 04; 72(1):162-177.e7.
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c-Myb regulates transcriptional activation of miR-143/145 in vascular smooth muscle cells. PLoS One. 2018; 13(8):e0202778.
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The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. Genetics. 2018 03; 208(3):937-949.
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Functional assessment of human enhancer activities using whole-genome STARR-sequencing. Genome Biol. 2017 Nov 20; 18(1):219.
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Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks. Cancer Res. 2017 12 01; 77(23):6538-6550.