Nucleic Acid Denaturation
"Nucleic Acid Denaturation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
| Descriptor ID |
D009691
|
| MeSH Number(s) |
E05.393.640 G02.111.603 G05.627
|
| Concept/Terms |
Nucleic Acid Denaturation- Nucleic Acid Denaturation
- Acid Denaturation, Nucleic
- Denaturation, Nucleic Acid
- Nucleic Acid Denaturations
|
Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Denaturation".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Denaturation".
This graph shows the total number of publications written about "Nucleic Acid Denaturation" by people in this website by year, and whether "Nucleic Acid Denaturation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nucleic Acid Denaturation" by people in Profiles.
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A new twist on V(D)J recombination. Nat Struct Mol Biol. 2018 08; 25(8):648-649.
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Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability. ACS Chem Biol. 2016 Feb 19; 11(2):470-7.
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Denaturing high-performance liquid chromatography for mutation detection and genotyping. Methods Mol Biol. 2013; 1015:25-54.
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G-quadruplex and i-motif are mutually exclusive in ILPR double-stranded DNA. Biophys J. 2012 Jun 06; 102(11):2575-84.
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Upgrading SELEX technology by using lambda exonuclease digestion for single-stranded DNA generation. Molecules. 2009 Dec 24; 15(1):1-11.
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The poly dA helix: a new structural motif for high performance DNA-based molecular switches. Nucleic Acids Res. 2009 May; 37(9):2810-7.
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Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs. Nucleic Acids Res. 2008 Jul; 36(12):e72.
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Kinetic barriers and the role of topology in protein and RNA folding. Protein Sci. 2008 Aug; 17(8):1308-18.
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The RNA2-PNA2 hybrid i-motif-a novel RNA-based building block. Chem Commun (Camb). 2008 Jan 07; (1):70-2.
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Real-time PCR for detection and identification of Plasmodium spp. J Clin Microbiol. 2005 May; 43(5):2435-40.