"Codon, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.
| Descriptor ID |
D018387
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| MeSH Number(s) |
D13.444.735.544.355.225 G05.360.335.355.225 G05.360.340.024.340.137.190.225
|
| Concept/Terms |
Codon, Initiator- Codon, Initiator
- Codons, Initiator
- Initiator Codons
- Initiator Codon
- Start Codon
- Codon, Start
- Codons, Start
- Start Codons
- Codon, Initiation
- Codons, Initiation
- Initiation Codon
- Initiation Codons
|
Below are MeSH descriptors whose meaning is more general than "Codon, Initiator".
Below are MeSH descriptors whose meaning is more specific than "Codon, Initiator".
This graph shows the total number of publications written about "Codon, Initiator" by people in this website by year, and whether "Codon, Initiator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Codon, Initiator" by people in Profiles.
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Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease. Nat Commun. 2024 Jul 09; 15(1):5748.
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Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons. Elife. 2023 09 07; 12.
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Kozak Similarity Score Algorithm Identifies Alternative Translation Initiation Codons Implicated in Cancers. Int J Mol Sci. 2022 Sep 12; 23(18).
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Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions. PLoS One. 2022; 17(6):e0256411.
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The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. Nature. 2016 Feb 25; 530(7591):441-6.
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Reinitiation of mRNA translation in a patient with X-linked infantile spasms with a protein-truncating variant in ARX. Eur J Hum Genet. 2016 May; 24(5):681-9.
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Unique features of the m6A methylome in Arabidopsis thaliana. Nat Commun. 2014 Nov 28; 5:5630.
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Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I. Science. 2012 Jun 29; 336(6089):1719-23.
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Role of helix 44 of 16S rRNA in the fidelity of translation initiation. RNA. 2012 Mar; 18(3):485-95.
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NMR detection of structures in the HIV-1 5'-leader RNA that regulate genome packaging. Science. 2011 Oct 14; 334(6053):242-5.