Receptor, Platelet-Derived Growth Factor alpha
"Receptor, Platelet-Derived Growth Factor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.
| Descriptor ID |
D020796
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.900.500 D12.776.543.750.630.625.300 D12.776.543.750.750.400.630.300
|
| Concept/Terms |
Receptor, Platelet-Derived Growth Factor alpha- Receptor, Platelet-Derived Growth Factor alpha
- Platelet-Derived Growth Factor alpha Receptor
- Platelet Derived Growth Factor alpha Receptor
- Antigens, CD140a
- PDGFRalpha
- PDGF-R-alpha
- Receptor, PDGF alpha
- CD140a Antigen
- Antigen, CD140a
- PDGFR2
- PDGF alpha Receptor
- CD140a Antigens
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Platelet-Derived Growth Factor alpha".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
- Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
- Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
- Receptor, Platelet-Derived Growth Factor alpha [D08.811.913.696.620.682.725.400.900.500]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
- Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
- Receptor, Platelet-Derived Growth Factor alpha [D12.776.543.750.630.625.300]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Platelet-Derived Growth Factor [D12.776.543.750.750.400.630]
- Receptor, Platelet-Derived Growth Factor alpha [D12.776.543.750.750.400.630.300]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Platelet-Derived Growth Factor alpha".
This graph shows the total number of publications written about "Receptor, Platelet-Derived Growth Factor alpha" by people in this website by year, and whether "Receptor, Platelet-Derived Growth Factor alpha" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 2 | 0 | 2 |
| 2017 | 1 | 2 | 3 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Receptor, Platelet-Derived Growth Factor alpha" by people in Profiles.
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Mesothelial cells are not a source of adipocytes in mice. Cell Rep. 2021 07 13; 36(2):109388.
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Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Cancer Res. 2019 08 15; 79(16):4026-4041.
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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. J Cell Biol. 2017 11 06; 216(11):3799-3816.
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Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms. Biochim Biophys Acta Rev Cancer. 2017 Dec; 1868(2):372-393.
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A phase II study of a human anti-PDGFRa monoclonal antibody (olaratumab, IMC-3G3) in previously treated patients with metastatic gastrointestinal stromal tumors. Ann Oncol. 2017 03 01; 28(3):541-546.
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Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Cell Rep. 2017 01 24; 18(4):961-976.
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Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development. 2014 Feb; 141(3):548-55.
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A 32-year-old man with persistent cough, shortness of breath, eosinophilic pneumonia, and peripheral blood eosinophilia. Myeloid neoplasm associated with eosinophilia and platelet-derived growth factor receptor-alpha rearrangement. Chest. 2012 Dec; 142(6):1680-1683.
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PDGF-a stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 01; 302(11):G1274-81.
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Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar; 122(3):911-22.