Microphthalmia-Associated Transcription Factor
"Microphthalmia-Associated Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
| Descriptor ID |
D051739
|
| MeSH Number(s) |
D12.776.260.103.500.500 D12.776.260.108.092.500 D12.776.930.125.500.500 D12.776.930.127.092.500
|
| Concept/Terms |
Microphthalmia-Associated Transcription Factor- Microphthalmia-Associated Transcription Factor
- Microphthalmia Associated Transcription Factor
- Transcription Factor, Microphthalmia-Associated
- MITF Transcription Factor
- Transcription Factor Microphthalmia
- Microphthalmia, Transcription Factor
- MITF Protein
|
Below are MeSH descriptors whose meaning is more general than "Microphthalmia-Associated Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Microphthalmia-Associated Transcription Factor".
This graph shows the total number of publications written about "Microphthalmia-Associated Transcription Factor" by people in this website by year, and whether "Microphthalmia-Associated Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Microphthalmia-Associated Transcription Factor" by people in Profiles.
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Autophagy and cancer cell metabolism. Int Rev Cell Mol Biol. 2019; 347:145-190.
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Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations. J Hum Genet. 2018 May; 63(5):639-646.
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High prevalence of MiTF staining in undifferentiated pleomorphic sarcoma: caution in the use of melanocytic markers in sarcoma. Histopathology. 2017 Apr; 70(5):734-745.
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BPTF transduces MITF-driven prosurvival signals in melanoma cells. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6254-8.
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Expression of MiTF may be helpful in differentiating cellular neurothekeoma from plexiform fibrohistiocytic tumor (histiocytoid predominant) in a partial biopsy specimen. Am J Dermatopathol. 2012 Apr; 34(2):157-60.
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c-Met is a potentially new therapeutic target for treatment of human melanoma. Clin Cancer Res. 2007 Apr 01; 13(7):2246-53.
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Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature. 2005 Feb 24; 433(7028):884-7.
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Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. Hum Mol Genet. 2003 Apr 15; 12(8):937-45.