Nuclear Receptor Coactivator 1
"Nuclear Receptor Coactivator 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a HISTONE ACETYLTRANSFRASE activity that may play a role in the transcriptional activation of CHROMATIN regions.
| Descriptor ID |
D056920
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| MeSH Number(s) |
D08.811.913.050.134.415.500.100 D12.644.360.024.314.100 D12.776.157.057.080.100 D12.776.260.103.782 D12.776.476.024.394.100 D12.776.660.675.100 D12.776.930.125.500.625 D12.776.930.617.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Coactivator 1".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Coactivator 1".
This graph shows the total number of publications written about "Nuclear Receptor Coactivator 1" by people in this website by year, and whether "Nuclear Receptor Coactivator 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nuclear Receptor Coactivator 1" by people in Profiles.
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Recurrent MEIS1-NCOA2/1 fusions in a subset of low-grade spindle cell sarcomas frequently involving the genitourinary and gynecologic tracts. Mod Pathol. 2021 06; 34(6):1203-1212.
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Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009 Nov; 29(10):1569-81.
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In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice. Endocrinology. 2009 Aug; 150(8):3927-34.
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Identification of regions within the F domain of the human estrogen receptor alpha that are important for modulating transactivation and protein-protein interactions. Mol Endocrinol. 2007 Apr; 21(4):829-42.
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Regulation of nuclear coactivator and corepressor expression in mouse cerebellum by thyroid hormone. Thyroid. 2006 Mar; 16(3):211-6.
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A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone. J Clin Endocrinol Metab. 2006 May; 91(5):1887-95.
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Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest. 2005 Sep; 115(9):2517-23.
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Thyroid hormone receptor subtypes and their interaction with steroid receptor coactivators. Vitam Horm. 2004; 68:185-207.
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Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone. Mol Cell Endocrinol. 2003 May 30; 203(1-2):65-75.
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Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary. Mol Endocrinol. 2003 May; 17(5):882-94.