HSP27 Heat-Shock Proteins
"HSP27 Heat-Shock Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subfamily of small heat-shock proteins that function as molecular chaperones that aid in refolding of non-native proteins. They play a protective role that increases cellular survival during times of stress.
| Descriptor ID |
D055551
|
| MeSH Number(s) |
D12.776.580.216.270.625
|
| Concept/Terms |
HSP27 Heat-Shock Proteins- HSP27 Heat-Shock Proteins
- HSP27 Heat Shock Proteins
- Heat-Shock Proteins, HSP27
- HSP27 Protein
- HSP27 Proteins
- Heat Shock Protein beta-1
- Heat Shock Protein beta 1
- Heat-Shock Protein 27
- Heat Shock Protein 27
- Protein 27, Heat-Shock
- Heat-Shock Proteins 27
- Heat Shock Proteins 27
|
Below are MeSH descriptors whose meaning is more general than "HSP27 Heat-Shock Proteins".
Below are MeSH descriptors whose meaning is more specific than "HSP27 Heat-Shock Proteins".
This graph shows the total number of publications written about "HSP27 Heat-Shock Proteins" by people in this website by year, and whether "HSP27 Heat-Shock Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 3 | 4 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 2 | 2 |
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Below are the most recent publications written about "HSP27 Heat-Shock Proteins" by people in Profiles.
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Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors. Invest New Drugs. 2015 Aug; 33(4):921-30.
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Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease. Gastroenterology. 2015 Sep; 149(3):681-91.e10.
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Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1a pathway. FASEB J. 2014 Oct; 28(10):4324-34.
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Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation. Int J Oncol. 2014 May; 44(5):1490-8.
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Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection. Int J Colorectal Dis. 2012 Aug; 27(8):1039-46.
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AMP-18 facilitates assembly and stabilization of tight junctions to protect the colonic mucosal barrier. Inflamm Bowel Dis. 2012 Sep; 18(9):1749-59.
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Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G181-7.
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HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption. Microvasc Res. 2011 Mar; 81(2):189-97.
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MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Blood. 2011 Feb 24; 117(8):2527-37.
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Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2164-73.