Transforming Growth Factor beta2
"Transforming Growth Factor beta2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
| Descriptor ID |
D053781
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| MeSH Number(s) |
D12.644.276.374.687.200 D12.644.276.954.775.200 D12.776.467.374.687.200 D12.776.467.942.775.200 D23.529.374.687.200 D23.529.942.775.200
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| Concept/Terms |
Transforming Growth Factor beta2- Transforming Growth Factor beta2
- Glioblastoma-Derived T-Cell Suppressor Factor
- Glioblastoma Derived T Cell Suppressor Factor
- Cartilage-Inducing Factor-B
- Cartilage Inducing Factor B
- Polyergin
- TGF-beta2
- TGF-beta-2
- BSC-1 Cell Growth Inhibitor
- BSC 1 Cell Growth Inhibitor
- Suppressor Factor, T-Cell, Glioblastoma-Derived
|
Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta2".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta2".
This graph shows the total number of publications written about "Transforming Growth Factor beta2" by people in this website by year, and whether "Transforming Growth Factor beta2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta2" by people in Profiles.
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Common variation in a long non-coding RNA gene modulates variation of circulating TGF-ß2 levels in metastatic colorectal cancer patients (Alliance). BMC Genomics. 2024 May 14; 25(1):473.
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ß-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. Mol Metab. 2021 11; 53:101289.
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P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation. Am J Respir Cell Mol Biol. 2019 02; 60(2):221-231.
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ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells. PLoS One. 2015; 10(7):e0132661.
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Transforming growth factor-ß2 is sequestered in preterm human milk by chondroitin sulfate proteoglycans. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G171-80.
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Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor ß1-3 (TGF-ß1-3). J Biol Chem. 2014 Dec 05; 289(49):33971-83.
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TGF-ß affects enterocyte turnover in correlation with TGF-ß receptor expression after massive small bowel resection. J Pediatr Gastroenterol Nutr. 2012 Dec; 55(6):721-7.
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Smad7 inhibits autocrine expression of TGF-ß2 in intestinal epithelial cells in baboon necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G167-80.
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HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. J Clin Invest. 2012 Oct; 122(10):3603-17.
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Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development. Development. 2009 Jun; 136(12):2081-9.