"Strychnine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.
| Descriptor ID |
D013331
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| MeSH Number(s) |
D03.132.436.681.722 D03.633.100.473.402.681.722
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Strychnine".
Below are MeSH descriptors whose meaning is more specific than "Strychnine".
This graph shows the total number of publications written about "Strychnine" by people in this website by year, and whether "Strychnine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Strychnine" by people in Profiles.
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Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nat Commun. 2023 03 13; 14(1):1363.
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Strychnine: Old Remedy, Silent Killer. Pediatr Ann. 2019 May 01; 48(5):e205-e207.
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The interdependence of excitation and inhibition for the control of dynamic breathing rhythms. Nat Commun. 2018 02 26; 9(1):843.
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Characterization of two mutations, M287L and Q266I, in the a1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther. 2012 Feb; 340(2):304-16.
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Differential modulation of neural network and pacemaker activity underlying eupnea and sigh-breathing activities. J Neurophysiol. 2008 May; 99(5):2114-25.
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GABA(A) receptors in the rostral ventrolateral medulla mediate the depressor response induced by stimulation of the greater splanchnic nerve afferent fibres in rats. Neurosci Lett. 1998 Jun 19; 249(2-3):95-8.
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Comparisons between strychnine and penicillin epileptogenesis suggest that propagating epileptiform abnormalities require the potentiation of thalamocortical circuitry in neocortical layer 4. Exp Neurol. 1988 May; 100(2):365-80.