Receptor Tyrosine Kinase-like Orphan Receptors
"Receptor Tyrosine Kinase-like Orphan Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.
| Descriptor ID |
D057050
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.093 D12.776.543.750.630.233
|
| Concept/Terms |
Receptor Tyrosine Kinase-like Orphan Receptors- Receptor Tyrosine Kinase-like Orphan Receptors
- Receptor Tyrosine Kinase like Orphan Receptors
- Neurotrophic Tyrosine Kinase, Receptor-related Proteins
- Neurotrophic Tyrosine Kinase, Receptor related Proteins
- NTRKR Receptors
- ROR Tyrosine Kinase Receptors
|
Below are MeSH descriptors whose meaning is more general than "Receptor Tyrosine Kinase-like Orphan Receptors".
Below are MeSH descriptors whose meaning is more specific than "Receptor Tyrosine Kinase-like Orphan Receptors".
This graph shows the total number of publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in this website by year, and whether "Receptor Tyrosine Kinase-like Orphan Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in Profiles.
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Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1. Theranostics. 2018; 8(10):2739-2751.
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Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing. Am J Hum Genet. 2016 05 05; 98(5):843-856.
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miR-27b-3p suppresses cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer. J Exp Clin Cancer Res. 2015 Nov 14; 34:139.
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Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci. 2009 Jul; 100(7):1227-33.
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Robinow syndrome: phenotypic variability in a family with a novel intragenic ROR2 mutation. Am J Med Genet A. 2008 Nov 01; 146A(21):2804-9.