"Central Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is accomplished by CLONAL ANERGY and CLONAL DELETION.
| Descriptor ID |
D061167
|
| MeSH Number(s) |
G12.535.425.800.200
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Central Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Central Tolerance".
This graph shows the total number of publications written about "Central Tolerance" by people in this website by year, and whether "Central Tolerance" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Central Tolerance" by people in Profiles.
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Rapid chromatin repression by Aire provides precise control of immune tolerance. Nat Immunol. 2018 02; 19(2):162-172.
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Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. Cell Rep. 2016 10 04; 17(2):387-398.
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Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med. 2014 May 05; 211(5):761-8.