"Interleukin-11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lymphohematopoietic cytokine that plays a role in regulating the proliferation of ERYTHROID PRECURSOR CELLS. It induces maturation of MEGAKARYOCYTES which results in increased production of BLOOD PLATELETS. Interleukin-11 was also initially described as an inhibitor of ADIPOGENESIS of cultured preadipocytes.
| Descriptor ID |
D017370
|
| MeSH Number(s) |
D12.644.276.374.465.511 D12.776.467.374.465.511 D23.529.374.465.511
|
| Concept/Terms |
Interleukin-11- Interleukin-11
- Interleukin 11
- IL-11
- IL11
- Adipogenesis Inhibitory Factor
- Factor, Adipogenesis Inhibitory
- Inhibitory Factor, Adipogenesis
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-11".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-11".
This graph shows the total number of publications written about "Interleukin-11" by people in this website by year, and whether "Interleukin-11" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interleukin-11" by people in Profiles.
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IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFß. Front Immunol. 2024; 15:1293883.
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miR-206 Inhibits Stemness and Metastasis of Breast Cancer by Targeting MKL1/IL11 Pathway. Clin Cancer Res. 2017 Feb 15; 23(4):1091-1103.
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Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment. Glia. 2014 Jul; 62(7):1176-94.
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MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun. 2013; 4:1393.
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MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat. 2013 Jan; 137(2):373-82.
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TGFß-dependent induction of interleukin-11 and interleukin-8 involves SMAD and p38 MAPK pathways in breast tumor models with varied bone metastases potential. Cancer Biol Ther. 2011 Feb 01; 11(3):311-6.
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Cold pre-conditioning neuroprotection depends on TNF-a and is enhanced by blockade of interleukin-11. J Neurochem. 2011 Apr; 117(2):187-96.
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Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress. Gastroenterology. 2003 May; 124(5):1358-68.
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Interleukin-11 for thrombocytopenia associated with hepatitis C. J Clin Gastroenterol. 2001 Nov-Dec; 33(5):425-6.
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Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease. Gastroenterology. 1999 Jul; 117(1):58-64.