Killer Cells, Lymphokine-Activated
"Killer Cells, Lymphokine-Activated" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.
| Descriptor ID |
D015979
|
| MeSH Number(s) |
A11.118.637.555.283.500 A11.118.637.555.567.537.500 A15.145.229.637.555.283.500 A15.145.229.637.555.567.537.500 A15.382.490.555.283.500 A15.382.490.555.567.537.500
|
| Concept/Terms |
Killer Cells, Lymphokine-Activated- Killer Cells, Lymphokine-Activated
- Cell, Lymphokine-Activated Killer
- Cells, Lymphokine-Activated Killer
- Killer Cell, Lymphokine-Activated
- Killer Cells, Lymphokine Activated
- Lymphokine-Activated Killer Cell
- Lymphokine-Activated Killer Cells
- Lymphokine Activated Killer Cells
- LAK Cells
- Cell, LAK
- Cells, LAK
- LAK Cell
|
Below are MeSH descriptors whose meaning is more general than "Killer Cells, Lymphokine-Activated".
- Anatomy [A]
- Cells [A11]
- Blood Cells [A11.118]
- Leukocytes [A11.118.637]
- Leukocytes, Mononuclear [A11.118.637.555]
- Cytokine-Induced Killer Cells [A11.118.637.555.283]
- Killer Cells, Lymphokine-Activated [A11.118.637.555.283.500]
- Lymphocytes [A11.118.637.555.567]
- Killer Cells, Natural [A11.118.637.555.567.537]
- Killer Cells, Lymphokine-Activated [A11.118.637.555.567.537.500]
- Hemic and Immune Systems [A15]
- Blood [A15.145]
- Blood Cells [A15.145.229]
- Leukocytes [A15.145.229.637]
- Leukocytes, Mononuclear [A15.145.229.637.555]
- Cytokine-Induced Killer Cells [A15.145.229.637.555.283]
- Killer Cells, Lymphokine-Activated [A15.145.229.637.555.283.500]
- Lymphocytes [A15.145.229.637.555.567]
- Killer Cells, Natural [A15.145.229.637.555.567.537]
- Killer Cells, Lymphokine-Activated [A15.145.229.637.555.567.537.500]
- Immune System [A15.382]
- Leukocytes [A15.382.490]
- Leukocytes, Mononuclear [A15.382.490.555]
- Cytokine-Induced Killer Cells [A15.382.490.555.283]
- Killer Cells, Lymphokine-Activated [A15.382.490.555.283.500]
- Lymphocytes [A15.382.490.555.567]
- Killer Cells, Natural [A15.382.490.555.567.537]
- Killer Cells, Lymphokine-Activated [A15.382.490.555.567.537.500]
Below are MeSH descriptors whose meaning is more specific than "Killer Cells, Lymphokine-Activated".
This graph shows the total number of publications written about "Killer Cells, Lymphokine-Activated" by people in this website by year, and whether "Killer Cells, Lymphokine-Activated" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 3 | 0 | 3 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Killer Cells, Lymphokine-Activated" by people in Profiles.
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Immunosensitization with a Bcl-2 small molecule inhibitor. Cancer Immunol Immunother. 2009 May; 58(5):699-708.
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Molecular basis of the dual functions of 2B4 (CD244). J Immunol. 2008 Jun 15; 180(12):8159-67.
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2B4 inhibits NK-cell fratricide. Blood. 2007 Sep 15; 110(6):2020-3.
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SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. Blood. 2005 Feb 01; 105(3):1153-61.
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Immunological and clinical effects of post-transplant G-CSF versus placebo in T-cell replete allogeneic blood transplant patients: results from a randomized double-blind study. Cytotherapy. 2003; 5(6):542-52.
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Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors. Blood. 2000 Feb 15; 95(4):1465-72.
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Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 1999 May 01; 162(9):5345-50.
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Donor pretreatment with Flt-3 ligand augments antidonor cytotoxic T lymphocyte, natural killer, and lymphokine-activated killer cell activities within liver allografts and alters the pattern of intragraft apoptotic activity. Transplantation. 1998 Jun 27; 65(12):1590-8.
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Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell Immunol. 1997 Aug 25; 180(1):1-9.
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Autologous lymphokine-activated killer cell therapy of Epstein-Barr virus-positive and -negative lymphoproliferative disorders arising in organ transplant recipients. Transplantation. 1997 May 15; 63(9):1200-5.