"Mice, Inbred CFTR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.
| Descriptor ID |
D018181
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| MeSH Number(s) |
B01.050.050.199.520.520.445 B01.050.150.900.649.313.992.635.505.500.400.445
|
| Concept/Terms |
Mice, Inbred CFTR- Mice, Inbred CFTR
- CFTR Mice, Inbred
- Inbred CFTR Mice
- Mouse, Inbred CFTR
- CFTR Mouse, Inbred
- Inbred CFTR Mouse
- Mice, CFTR
- CFTR Mice
- Mouse, CFTR
- CFTR Mouse
|
Below are MeSH descriptors whose meaning is more general than "Mice, Inbred CFTR".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred CFTR".
This graph shows the total number of publications written about "Mice, Inbred CFTR" by people in this website by year, and whether "Mice, Inbred CFTR" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Inbred CFTR" by people in Profiles.
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Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota. Dig Dis Sci. 2013 Mar; 58(3):668-77.
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Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages. J Biol Chem. 2009 Dec 18; 284(51):35926-38.