"Hexamethonium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
| Descriptor ID |
D018738
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| MeSH Number(s) |
D02.092.877.250.592.400 D02.675.276.558.592.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hexamethonium".
Below are MeSH descriptors whose meaning is more specific than "Hexamethonium".
This graph shows the total number of publications written about "Hexamethonium" by people in this website by year, and whether "Hexamethonium" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hexamethonium" by people in Profiles.
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Hexamethonium attenuates sympathetic activity and blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2015 Nov; 12(5):7116-22.
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Mechanisms of sustained cutaneous vasodilation induced by spinal cord stimulation. Auton Neurosci. 2004 Jul 30; 114(1-2):55-60.
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Local cooling alters neural mechanisms producing changes in peripheral blood flow by spinal cord stimulation. Auton Neurosci. 2003 Mar 28; 104(2):117-27.
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Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release. Brain Res. 2001 Mar 30; 896(1-2):183-7.
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Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo. J Appl Physiol (1985). 1987 Feb; 62(2):599-605.
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Effect of focal cooling of central chemosensitive areas on cerebral ischemic response. Am J Physiol. 1986 Aug; 251(2 Pt 2):R295-302.
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Mechanism of the pressor action of LY171555, a specific dopamine D2 receptor agonist, in the conscious rat. J Pharmacol Exp Ther. 1986 Mar; 236(3):735-42.