"Apoptosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
| Descriptor ID |
D053478
|
| MeSH Number(s) |
D05.500.099
|
| Concept/Terms |
Apoptosomes- Apoptosomes
- Apoptosome
- Apoptosomal Protein Complex
- Complex, Apoptosomal Protein
- Protein Complex, Apoptosomal
|
Below are MeSH descriptors whose meaning is more general than "Apoptosomes".
Below are MeSH descriptors whose meaning is more specific than "Apoptosomes".
This graph shows the total number of publications written about "Apoptosomes" by people in this website by year, and whether "Apoptosomes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apoptosomes" by people in Profiles.
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Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol. 2014 Jul; 34(13):2450-63.