Protein Tyrosine Phosphatase, Non-Receptor Type 6
"Protein Tyrosine Phosphatase, Non-Receptor Type 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Src-homology domain-containing protein tyrosine phosphatase found in the CYTOSOL of hematopoietic cells. It plays a role in signal transduction by dephosphorylating signaling proteins that are activated or inactivated by PROTEIN-TYROSINE KINASES.
| Descriptor ID |
D053824
|
| MeSH Number(s) |
D08.811.277.352.650.775.300.600 D08.811.277.352.650.775.700.200 D12.644.360.585.600 D12.644.360.800.200 D12.776.476.564.600 D12.776.476.800.200
|
| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 6- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatase, Non Receptor Type 6
- Protein Tyrosine Phosphatase, Nonreceptor Type 6
- SHP1 Protein Tyrosine Phosphatase
- Hematopoietic Cell Phosphatase
- Protein Tyrosine Phosphatase 1C
- Hematopoietic Cell-Specific Tyrosine Phosphatase SHP-1
- Hematopoietic Cell Specific Tyrosine Phosphatase SHP 1
- SHP-1 Phosphatase
- SHP 1 Phosphatase
- SHP1 Phosphatase
- SHP-1 Protein-Tyrosine Phosphatase
- Protein-Tyrosine Phosphatase, SHP-1
- SHP 1 Protein Tyrosine Phosphatase
- SHP-1 Tyrosine Phosphatase
- SHP 1 Tyrosine Phosphatase
- Tyrosine Phosphatase, SHP-1
- Haematopoietic Cell Phosphatase
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 6".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Monoester Hydrolases [D08.811.277.352.650]
- Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
- Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D08.811.277.352.650.775.300.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D08.811.277.352.650.775.700.200]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.644.360.585.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.644.360.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.644.360.800.200]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.776.476.564.600]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 [D12.776.476.800.200]
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 6".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 6" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 6" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 6" by people in Profiles.
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Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks. Clin Cancer Res. 2019 09 15; 25(18):5638-5649.
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Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol. 2011 Apr; 178(4):1701-14.
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Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses. Am J Pathol. 2011 Apr; 178(4):1434-41.
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Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1. J Biol Chem. 2005 Nov 25; 280(47):39294-301.
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Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders. Lab Invest. 2002 Nov; 82(11):1599-606.
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Engagement of Gab1 and Gab2 in erythropoietin signaling. J Biol Chem. 1999 Aug 27; 274(35):24469-74.
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Defective expression of the SHP-1 phosphatase in polycythemia vera. Exp Hematol. 1999 Jul; 27(7):1124-32.
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Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. J Immunol. 1999 Feb 01; 162(3):1270-7.
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Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases. J Biol Chem. 1998 May 22; 273(21):13223-9.
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The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors. Oncogene. 1997 Nov 06; 15(19):2379-84.