Dual Specificity Phosphatase 1
"Dual Specificity Phosphatase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
| Descriptor ID |
D054638
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| MeSH Number(s) |
D08.811.277.352.650.587.200 D08.811.277.352.650.625.225.200 D08.811.277.352.650.775.250.200 D08.811.641.755.200 D12.644.360.268.200 D12.644.360.445.100 D12.776.476.268.200 D12.776.476.445.200
|
| Concept/Terms |
Dual Specificity Phosphatase 1- Dual Specificity Phosphatase 1
- CL100 Phosphatase
- Phosphatase, CL100
- Externally Regulated Phosphatase (ERP)
- MKP-1 Phosphatase
- MKP 1 Phosphatase
- Phosphatase, MKP-1
- MAP Phosphatase-1
- MAP Phosphatase 1
- Phosphatase-1, MAP
- MAPK Phosphatase
- Phosphatase, MAPK
- Mitogen-Activated Protein Phosphatase-1
- Mitogen Activated Protein Phosphatase 1
- Phosphatase-1, Mitogen-Activated Protein
- Protein Phosphatase-1, Mitogen-Activated
- 3CH134 Phosphatase
- Phosphatase, 3CH134
- Map Kinase Phosphatase 1
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Below are MeSH descriptors whose meaning is more general than "Dual Specificity Phosphatase 1".
Below are MeSH descriptors whose meaning is more specific than "Dual Specificity Phosphatase 1".
This graph shows the total number of publications written about "Dual Specificity Phosphatase 1" by people in this website by year, and whether "Dual Specificity Phosphatase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 1 | 3 |
| 2013 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dual Specificity Phosphatase 1" by people in Profiles.
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Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nat Med. 2017 Apr; 23(4):472-482.
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Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer. Clin Cancer Res. 2013 Nov 15; 19(22):6163-72.
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Mitogen-activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone. J Endocrinol. 2011 Nov; 211(2):145-56.
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Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity. 2011 Jul 22; 35(1):45-58.
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Protein kinase B (Akt) and mitogen-activated protein kinase p38a in retinal ischemic post-conditioning. J Mol Neurosci. 2011 Oct; 45(2):309-20.
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Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Exp Eye Res. 2011 Oct; 93(4):340-9.
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Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues. Clin Cancer Res. 2009 May 01; 15(9):3196-204.
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The MAP kinase phosphatase-1 MKP-1/DUSP1 is a regulator of human liver response to transplantation. Am J Transplant. 2008 Dec; 8(12):2558-68.
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Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem. 2005 Feb 11; 280(6):4117-24.
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Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res. 2004 Mar 01; 64(5):1757-64.