Microtubule-Organizing Center
"Microtubule-Organizing Center" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An amorphous region of electron dense material in the cytoplasm from which the MICROTUBULES polymerization is nucleated. The pericentriolar region of the CENTROSOME which surrounds the CENTRIOLES is an example.
| Descriptor ID |
D022101
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| MeSH Number(s) |
A11.284.430.214.190.750.585
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microtubule-Organizing Center".
Below are MeSH descriptors whose meaning is more specific than "Microtubule-Organizing Center".
This graph shows the total number of publications written about "Microtubule-Organizing Center" by people in this website by year, and whether "Microtubule-Organizing Center" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Microtubule-Organizing Center" by people in Profiles.
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DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130. Sci Rep. 2019 02 28; 9(1):3035.
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PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts. J Cell Sci. 2018 07 11; 131(13).
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LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model. Oncotarget. 2015 Sep 29; 6(29):27359-77.
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PKC? regulates T cell motility via ezrin-radixin-moesin localization to the uropod. PLoS One. 2013; 8(11):e78940.
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Sperm membrane protein (hSMP-1) and RanBPM complex in the microtubule-organizing centre. J Mol Med (Berl). 2004 Jun; 82(6):383-8.
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Maelstrom is required to position the MTOC in stage 2-6 Drosophila oocytes. Dev Genes Evol. 2001 Jan; 211(1):44-8.