T-Cell Intracellular Antigen-1
"T-Cell Intracellular Antigen-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An RNA-binding protein characterized by three RNA RECOGNITION MOTIFS. It binds to AU RICH ELEMENTS in the 3'-untranslated regions of mRNA and regulates alternative pre-RNA splicing and mRNA translation; it may also function in APOPTOSIS. Mutations in the TIA-1 gene are associated with WELANDER DISTAL MYOPATHY.
| Descriptor ID |
D000074019
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| MeSH Number(s) |
D12.776.157.725.452.750 D12.776.157.725.813.937 D12.776.157.725.829.875 D12.776.664.962.452.750 D12.776.664.962.813.937 D12.776.664.962.829.875
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| Concept/Terms |
T-Cell Intracellular Antigen-1- T-Cell Intracellular Antigen-1
- Intracellular Antigen-1, T-Cell
- T Cell Intracellular Antigen 1
- T-Cell-Restricted Intracellular Antigen-1
- Intracellular Antigen-1, T-Cell-Restricted
- T Cell Restricted Intracellular Antigen 1
- RNA-Binding Protein TIA-1
- RNA Binding Protein TIA 1
- TIA-1, RNA-Binding Protein
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Below are MeSH descriptors whose meaning is more general than "T-Cell Intracellular Antigen-1".
Below are MeSH descriptors whose meaning is more specific than "T-Cell Intracellular Antigen-1".
This graph shows the total number of publications written about "T-Cell Intracellular Antigen-1" by people in this website by year, and whether "T-Cell Intracellular Antigen-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "T-Cell Intracellular Antigen-1" by people in Profiles.
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TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017 Aug 16; 95(4):808-816.e9.
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Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G481-92.
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Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells. Biochem Soc Trans. 2004 Nov; 32(Pt 5):697-701.
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Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. J Virol. 2004 Aug; 78(16):8582-92.
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Cytotoxicity and apoptosis in human renal allografts: identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA. Lab Invest. 1997 May; 76(5):639-49.