"Forkhead Box Protein O3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.
Descriptor ID |
D000071316
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MeSH Number(s) |
D12.776.260.950.249.125 D12.776.930.977.249.125
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Concept/Terms |
Forkhead Box Protein O3- Forkhead Box Protein O3
- Forkhead in Rhabdomyosarcoma-Like 1 Protein
- Forkhead in Rhabdomyosarcoma Like 1 Protein
- FOXO3 Protein
- Protein, FOXO3
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Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein O3".
Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein O3".
This graph shows the total number of publications written about "Forkhead Box Protein O3" by people in this website by year, and whether "Forkhead Box Protein O3" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2000 | 0 | 1 | 1 |
2002 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2008 | 0 | 4 | 4 |
2009 | 0 | 2 | 2 |
2010 | 0 | 1 | 1 |
2011 | 0 | 2 | 2 |
2013 | 0 | 1 | 1 |
2018 | 2 | 1 | 3 |
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Below are the most recent publications written about "Forkhead Box Protein O3" by people in Profiles.
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Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1. J Immunol. 2019 01 15; 202(2):484-493.
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Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer. Nat Commun. 2018 12 05; 9(1):5200.
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Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover. Dev Cell. 2018 03 12; 44(5):555-565.e3.
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FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. J Biol Chem. 2013 Jun 07; 288(23):16274-16281.
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Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5594-9.
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes. Diabetes. 2011 Nov; 60(11):2883-91.
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Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer. 2011 Jun 03; 11:219.
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Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300(2):G264-72.
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Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest. 2009 Sep; 119(9):2758-71.
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Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. Lab Invest. 2009 Sep; 89(9):1053-62.