"Smoothened Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.
| Descriptor ID |
D000072086
|
| MeSH Number(s) |
D12.776.543.750.695.017.500 D12.776.543.750.850.500.500
|
| Concept/Terms |
Smoothened Receptor- Smoothened Receptor
- Receptor, Smoothened
- Smoothened Protein
- Smoothened Receptors
- Receptors, Smoothened
|
Below are MeSH descriptors whose meaning is more general than "Smoothened Receptor".
Below are MeSH descriptors whose meaning is more specific than "Smoothened Receptor".
This graph shows the total number of publications written about "Smoothened Receptor" by people in this website by year, and whether "Smoothened Receptor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Smoothened Receptor" by people in Profiles.
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Targeting Hedgehog Pathway and DNA Methyltransferases in Uterine Leiomyosarcoma Cells. Cells. 2020 12 31; 10(1).
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Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. PLoS Genet. 2019 05; 15(5):e1007711.
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A Recurrent Mosaic Mutation in SMO, Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome. Am J Hum Genet. 2016 06 02; 98(6):1256-1265.
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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013 Mar; 45(3):285-9.
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Activation of the Sonic Hedgehog pathway in thyroid neoplasms and its potential role in tumor cell proliferation. Endocr Relat Cancer. 2012 Apr; 19(2):167-79.
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Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell. 2009 Jun 05; 4(6):548-58.
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Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol. 2006 Apr; 7(4):418-26.