Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
"Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
| Descriptor ID |
D000072183
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| MeSH Number(s) |
D08.811.277.352.650.624.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
This graph shows the total number of publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in this website by year, and whether "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in Profiles.
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Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks. Clin Cancer Res. 2019 09 15; 25(18):5638-5649.
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SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL. J Biol Chem. 2001 Jan 26; 276(4):2451-8.
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The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors. Oncogene. 1997 Nov 06; 15(19):2379-84.