"Spastin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.
| Descriptor ID |
D000074181
|
| MeSH Number(s) |
D08.811.277.040.013.500.500 D08.811.277.040.025.024.500 D12.776.157.025.750.500 D12.776.220.600.450.465 D12.776.631.560.480
|
| Concept/Terms |
Spastin- Spastin
- Spastic Paraplegia 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Spastin".
Below are MeSH descriptors whose meaning is more specific than "Spastin".
This graph shows the total number of publications written about "Spastin" by people in this website by year, and whether "Spastin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Spastin" by people in Profiles.
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Meta-analysis of age at onset in spastin-associated hereditary spastic paraplegia provides no evidence for a correlation with mutational class. J Med Genet. 2003 Sep; 40(9):e106.
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Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology. 2000 Nov 14; 55(9):1388-90.