Lysine Acetyltransferase 5
"Lysine Acetyltransferase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
| Descriptor ID |
D000074443
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.062
|
| Concept/Terms |
Lysine Acetyltransferase 5- Lysine Acetyltransferase 5
- KAT5 (TIP60) Protein
- HIV-1-Tat Interactive Protein Tip60
- HIV 1 Tat Interactive Protein Tip60
- HTATIP
|
Below are MeSH descriptors whose meaning is more general than "Lysine Acetyltransferase 5".
Below are MeSH descriptors whose meaning is more specific than "Lysine Acetyltransferase 5".
This graph shows the total number of publications written about "Lysine Acetyltransferase 5" by people in this website by year, and whether "Lysine Acetyltransferase 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lysine Acetyltransferase 5" by people in Profiles.
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Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 2018 01; 28(1):111-125.
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Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion. Sci Rep. 2017 06 16; 7(1):3635.
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Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell. 2014 Feb 10; 25(2):210-25.
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Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat. Biochemistry. 1999 Jul 06; 38(27):8826-30.