Solute Carrier Family 12, Member 3
"Solute Carrier Family 12, Member 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.
| Descriptor ID |
D064486
|
| MeSH Number(s) |
D12.776.157.530.450.625.374.500 D12.776.157.530.937.750.750 D12.776.543.585.937.875.750
|
| Concept/Terms |
Solute Carrier Family 12, Member 3- Solute Carrier Family 12, Member 3
- SLC12A3 Protein
- Protein, SLC12A3
- SLC12A3 Cotransporter
- Cotransporter, SLC12A3
- Na-Cl Symporter
- Na Cl Symporter
- Symporter, Na-Cl
- Na-Cl Thiazide-Sensitive Cotransporter
- Cotransporter, Na-Cl Thiazide-Sensitive
- Na Cl Thiazide Sensitive Cotransporter
- Thiazide-Sensitive Cotransporter, Na-Cl
- Na-Cl Cotransporter
- Cotransporter, Na-Cl
- Na Cl Cotransporter
- Thiazide-Sensitive Sodium-Chloride Cotransporter
- Cotransporter, Thiazide-Sensitive Sodium-Chloride
- Sodium-Chloride Cotransporter, Thiazide-Sensitive
- Thiazide Sensitive Sodium Chloride Cotransporter
- NCCT Protein
- Protein, NCCT
|
Below are MeSH descriptors whose meaning is more general than "Solute Carrier Family 12, Member 3".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Family 12, Member 3".
This graph shows the total number of publications written about "Solute Carrier Family 12, Member 3" by people in this website by year, and whether "Solute Carrier Family 12, Member 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Solute Carrier Family 12, Member 3" by people in Profiles.
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CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension. Nat Commun. 2017 01 09; 8:14037.
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Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. 2016 07; 68(1):167-74.
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PTH modulation of NCC activity regulates TRPV5 Ca2+ reabsorption. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F144-51.
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A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells. J Biol Chem. 2014 Apr 25; 289(17):11791-11806.
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Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F645-52.
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RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter. Am J Physiol Renal Physiol. 2010 Aug; 299(2):F300-9.
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Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphisms. Diabetes. 2003 Nov; 52(11):2848-53.