"Saxitoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.
| Descriptor ID |
D012530
|
| MeSH Number(s) |
D03.633.100.759.794 D23.946.580.830
|
| Concept/Terms |
Saxitoxin- Saxitoxin
- Saxitonin
- Gonyaulax Toxin
- Toxin, Gonyaulax
- Mitilotoxin
|
Below are MeSH descriptors whose meaning is more general than "Saxitoxin".
Below are MeSH descriptors whose meaning is more specific than "Saxitoxin".
This graph shows the total number of publications written about "Saxitoxin" by people in this website by year, and whether "Saxitoxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
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Below are the most recent publications written about "Saxitoxin" by people in Profiles.
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Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. Biophys J. 2001 Feb; 80(2):698-706.
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Lidocaine alters activation gating of cardiac Na channels. Pflugers Arch. 2000 Apr; 439(6):814-21.
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Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. Biophys J. 1998 Dec; 75(6):2647-57.
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The guanidinium toxin binding site on the sodium channel. Jpn Heart J. 1996 Sep; 37(5):683-92.
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Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8. Am J Physiol. 1996 May; 270(5 Pt 1):C1522-31.
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A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. Biophys J. 1995 Nov; 69(5):1657-65.
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Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J Gen Physiol. 1994 Jan; 103(1):19-43.
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A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J. 1994 Jan; 66(1):1-13.
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Effect of external Ca2+ concentration on stretch-augmented natriuretic peptide secretion by rat atria. Am J Physiol. 1991 Apr; 260(4 Pt 1):C756-62.
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Gating currents associated with Na channels in canine cardiac Purkinje cells. J Gen Physiol. 1990 Mar; 95(3):439-57.