"Superantigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
| Descriptor ID |
D018089
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| MeSH Number(s) |
D23.050.820
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Superantigens".
Below are MeSH descriptors whose meaning is more specific than "Superantigens".
This graph shows the total number of publications written about "Superantigens" by people in this website by year, and whether "Superantigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 2 | 0 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 2001 | 2 | 0 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 3 | 0 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Superantigens" by people in Profiles.
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The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 2021 09 28; 118(39).
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Peptidoglycan Contribution to the B Cell Superantigen Activity of Staphylococcal Protein A. mBio. 2021 04 20; 12(2).
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B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 08 28; 11(507).
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Recurrent infections and immune evasion strategies of Staphylococcus aureus. Curr Opin Microbiol. 2012 Feb; 15(1):92-9.
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A superantigen interacts with leishmanial infection in antigen-presenting cells to regulate cytokine commitment of responding CD4 T cells. J Infect Dis. 2010 Oct 15; 202(8):1234-45.
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Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA. Eur J Biochem. 2004 Oct; 271(20):4075-83.
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Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infect Immun. 2004 Jun; 72(6):3187-94.
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Initial stages of mammary tumor virus infection are superantigen independent. J Immunol. 2004 May 01; 172(9):5582-7.
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Unique resistance of I/LnJ mice to a retrovirus is due to sustained interferon gamma-dependent production of virus-neutralizing antibodies. J Exp Med. 2003 Jan 20; 197(2):233-43.
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Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice. J Infect Dis. 2001 Jul 15; 184(2):166-73.