"PrPC Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
| Descriptor ID |
D018621
|
| MeSH Number(s) |
D12.776.785.340.500
|
| Concept/Terms |
PrPC Proteins- PrPC Proteins
- PrP-sen
- PrP sen
- Cp 33-35
- Scrapie Amyloid Precursor Protein
- Cp33-35, Scrapie
|
Below are MeSH descriptors whose meaning is more general than "PrPC Proteins".
Below are MeSH descriptors whose meaning is more specific than "PrPC Proteins".
This graph shows the total number of publications written about "PrPC Proteins" by people in this website by year, and whether "PrPC Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 1 | 2 |
| 1998 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "PrPC Proteins" by people in Profiles.
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Generation of human chronic wasting disease in transgenic mice. Acta Neuropathol Commun. 2021 09 26; 9(1):158.
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"Dual Disease" TgAD/GSS mice exhibit enhanced Alzheimer's disease pathology and reveal PrPC-dependent secretion of Aß. Sci Rep. 2019 06 12; 9(1):8524.
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Prion protein functions as a ferrireductase partner for ZIP14 and DMT1. Free Radic Biol Med. 2015 Jul; 84:322-330.
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Prion protein promotes kidney iron uptake via its ferrireductase activity. J Biol Chem. 2015 Feb 27; 290(9):5512-22.
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Myelin maintenance: axonal support required. Nat Neurosci. 2010 Mar; 13(3):275-7.
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Live cell fluorescence resonance energy transfer predicts an altered molecular association of heterologous PrPSc with PrPC. J Biol Chem. 2010 Mar 19; 285(12):8967-75.
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A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP. J Neurosci. 2009 Aug 12; 29(32):10072-80.
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Identifying key components of the PrPC-PrPSc replicative interface. J Biol Chem. 2008 Dec 05; 283(49):34021-8.
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The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc. J Virol. 2006 Sep; 80(17):8521-9.
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The AGAAAAGA palindrome in PrP is required to generate a productive PrPSc-PrPC complex that leads to prion propagation. J Biol Chem. 2005 Jul 22; 280(29):27236-43.