"Genes, erbB-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
| Descriptor ID |
D018773
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.295.300
|
| Concept/Terms |
Genes, erbB-1- Genes, erbB-1
- Genes, erbB1
- Gene, erbB1
- erbB1 Gene
- erbB1 Genes
- erbB-1 Genes
- erbB 1 Genes
- erbB-1 Gene
v-erbB Genes- v-erbB Genes
- v erbB Genes
- v-erbB Gene
- v-erbB Oncogenes
- v erbB Oncogenes
- v-erbB Oncogene
c-erbB-1 Genes- c-erbB-1 Genes
- c erbB 1 Genes
- c-erbB-1 Gene
- EGFR Genes
- Epidermal Growth Factor Receptor Genes
- c-erbB-1 Proto-Oncogenes
- c erbB 1 Proto Oncogenes
- c-erbB-1 Proto-Oncogene
- Genes, EGFR
- EGFR Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, erbB-1".
Below are MeSH descriptors whose meaning is more specific than "Genes, erbB-1".
This graph shows the total number of publications written about "Genes, erbB-1" by people in this website by year, and whether "Genes, erbB-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Genes, erbB-1" by people in Profiles.
-
A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non-small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations. Clin Cancer Res. 2017 Dec 15; 23(24):7467-7473.
-
ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non-Small Cell Lung Cancer. J Thorac Oncol. 2017 05; 12(5):872-877.
-
EGFR mutations and EGFR tyrosine kinase inhibitors. Lancet Oncol. 2015 Jul; 16(7):746-8.
-
Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer: EGFR and beyond. Chin J Cancer. 2015 Apr 08; 34(4):149-60.
-
Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer. Genes Chromosomes Cancer. 2011 May; 50(5):307-12.
-
Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. J Clin Pathol. 2011 Jan; 64(1):16-24.
-
Lung cancer: a biologically different disease in women? Womens Health (Lond). 2009 Nov; 5(6):685-91.
-
Predicting response of molecular targeted therapies: a still possible challenge? Ann Oncol. 2008 May; 19(5):829-30.
-
Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer Res. 2008 Jan 01; 68(1):132-42.