"Flap Endonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
| Descriptor ID |
D045585
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| MeSH Number(s) |
D08.811.277.352.355.325.350
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| Concept/Terms |
Flap Endonuclease-1- Flap Endonuclease-1
- Endonuclease-1, Flap
- Flap Endonuclease 1
- RTH-1 Nuclease
- Nuclease, RTH-1
- RTH 1 Nuclease
- RAD2 Homolog-1 Nuclease
- RAD2 Homolog 1 Nuclease
- FEN-1
- Fen1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Flap Endonucleases".
Below are MeSH descriptors whose meaning is more specific than "Flap Endonucleases".
This graph shows the total number of publications written about "Flap Endonucleases" by people in this website by year, and whether "Flap Endonucleases" was a major or minor topic of these publications.
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Below are the most recent publications written about "Flap Endonucleases" by people in Profiles.
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FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Mol Cancer Res. 2010 Feb; 8(2):204-15.
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Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol. 2005 Aug; 25(16):6948-55.
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Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus. OMICS. 2002; 6(3):273-9.