"MRE11 Homologue Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
| Descriptor ID |
D000076228
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| MeSH Number(s) |
D08.811.277.352.335.350.650 D08.811.277.352.335.375.813 D08.811.277.352.355.325.600 D08.811.277.352.365.290.250 D12.776.157.687.495 D12.776.260.539 D12.776.660.720.495
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| Concept/Terms |
MRE11 Homologue Protein- MRE11 Homologue Protein
- Homologue Protein, MRE11
- MRE11A Protein
- Meiotic Recombination 11 Homolog 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "MRE11 Homologue Protein".
Below are MeSH descriptors whose meaning is more specific than "MRE11 Homologue Protein".
This graph shows the total number of publications written about "MRE11 Homologue Protein" by people in this website by year, and whether "MRE11 Homologue Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "MRE11 Homologue Protein" by people in Profiles.
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Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer. JAMA Oncol. 2017 Sep 01; 3(9):1190-1196.
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Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. Cancer Res. 2009 Jul 15; 69(14):5801-10.