Apoptotic Protease-Activating Factor 1
"Apoptotic Protease-Activating Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
| Descriptor ID |
D053477
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| MeSH Number(s) |
D12.644.360.024.131.124 D12.644.360.075.358.124 D12.776.157.057.006.124 D12.776.476.024.139.124 D12.776.476.075.358.124
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| Concept/Terms |
Apoptotic Protease-Activating Factor 1- Apoptotic Protease-Activating Factor 1
- Apoptotic Protease Activating Factor 1
- Apaf-1 Protease-Activating Factor
- Apaf 1 Protease Activating Factor
- Protease-Activating Factor, Apaf-1
- Apoptotic Peptidase Activating Factor 1
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Below are MeSH descriptors whose meaning is more general than "Apoptotic Protease-Activating Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Apoptotic Protease-Activating Factor 1".
This graph shows the total number of publications written about "Apoptotic Protease-Activating Factor 1" by people in this website by year, and whether "Apoptotic Protease-Activating Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apoptotic Protease-Activating Factor 1" by people in Profiles.
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Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol. 2014 Jul; 34(13):2450-63.
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Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program. Cancer. 2013 Feb 15; 119(4):756-65.
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A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway. Hum Mol Genet. 2006 Oct 15; 15(20):3034-40.
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p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. Cancer Res. 2005 Feb 15; 65(4):1197-206.
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Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases. J Biol Chem. 2003 May 09; 278(19):16466-9.
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Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 2001 Sep; 3(9):839-43.
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Apaf-1 deficiency and neural tube closure defects are found in fog mice. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9683-7.
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Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J. 2000 Aug 15; 19(16):4310-22.
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Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3. Oncogene. 2000 Apr 13; 19(16):1975-81.