Nod2 Signaling Adaptor Protein
"Nod2 Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
| Descriptor ID |
D053473
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| MeSH Number(s) |
D12.644.360.024.131.500 D12.644.360.024.313.500 D12.644.360.075.358.500 D12.644.360.539.500.500 D12.776.157.057.006.500 D12.776.157.057.078.500 D12.776.476.024.139.500 D12.776.476.024.391.500 D12.776.476.075.358.500
|
| Concept/Terms |
Nod2 Signaling Adaptor Protein- Nod2 Signaling Adaptor Protein
- CARD15 Protein
- Nucleotide Oligomerization Domain 2 Protein
- Caspase Recruitment Domain Protein 15
|
Below are MeSH descriptors whose meaning is more general than "Nod2 Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "Nod2 Signaling Adaptor Protein".
This graph shows the total number of publications written about "Nod2 Signaling Adaptor Protein" by people in this website by year, and whether "Nod2 Signaling Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nod2 Signaling Adaptor Protein" by people in Profiles.
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Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis. Mucosal Immunol. 2017 07; 10(4):971-982.
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NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells. Inflamm Bowel Dis. 2014 Jan; 20(1):126-35.
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Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation. Mol Biol Evol. 2012 Jun; 29(6):1569-85.
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Endothelial and epithelial barriers in graft-versus-host disease. Adv Exp Med Biol. 2012; 763:105-31.
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Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population. Int J Hematol. 2011 Jun; 93(6):771-778.
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Inflammatory bowel disease. Expert Rev Clin Immunol. 2010 Jul; 6(4):499-500.
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Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. Am J Gastroenterol. 2006 Mar; 101(3):572-80.
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To test or "NOD-2" test: what are the questions? The balanced viewpoint. Inflamm Bowel Dis. 2005 May; 11(5):510-2.
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Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum Mol Genet. 2004 Aug 15; 13(16):1715-25.
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Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes. Inflamm Bowel Dis. 2003 Sep; 9(5):281-9.