Ribonuclease H, Human Immunodeficiency Virus
"Ribonuclease H, Human Immunodeficiency Virus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ribonuclease activity that is a component of the HIV REVERSE TRANSCRIPTASE. It removes the RNA strand of the RNA-DNA heteroduplex produced by reverse transcription. Once the RNA moiety is removed a double stranded DNA copy of the HIV RNA can be synthesized.
| Descriptor ID |
D054309
|
| MeSH Number(s) |
D08.811.277.352.355.350.700.500 D08.811.277.352.700.350.700.500 D12.776.964.775.375.545.875.500 D12.776.964.775.562.764.875.500 D12.776.964.970.600.850.375.545.875.500 D12.776.964.970.600.850.375.750.187.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ribonuclease H, Human Immunodeficiency Virus".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Endonucleases [D08.811.277.352.355]
- Endoribonucleases [D08.811.277.352.355.350]
- Ribonuclease H [D08.811.277.352.355.350.700]
- Ribonuclease H, Human Immunodeficiency Virus [D08.811.277.352.355.350.700.500]
- Ribonucleases [D08.811.277.352.700]
- Endoribonucleases [D08.811.277.352.700.350]
- Ribonuclease H [D08.811.277.352.700.350.700]
- Ribonuclease H, Human Immunodeficiency Virus [D08.811.277.352.700.350.700.500]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Viral Proteins [D12.776.964]
- Retroviridae Proteins [D12.776.964.775]
- Gene Products, pol [D12.776.964.775.375]
- pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.375.545]
- HIV Reverse Transcriptase [D12.776.964.775.375.545.875]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.775.375.545.875.500]
- Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
- pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.764]
- HIV Reverse Transcriptase [D12.776.964.775.562.764.875]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.775.562.764.875.500]
- Viral Structural Proteins [D12.776.964.970]
- Nucleocapsid Proteins [D12.776.964.970.600]
- Viral Core Proteins [D12.776.964.970.600.850]
- Gene Products, pol [D12.776.964.970.600.850.375]
- pol Gene Products, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545]
- HIV Reverse Transcriptase [D12.776.964.970.600.850.375.545.875]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545.875.500]
- RNA-Directed DNA Polymerase [D12.776.964.970.600.850.375.750]
- HIV Reverse Transcriptase [D12.776.964.970.600.850.375.750.187]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.750.187.500]
Below are MeSH descriptors whose meaning is more specific than "Ribonuclease H, Human Immunodeficiency Virus".
This graph shows the total number of publications written about "Ribonuclease H, Human Immunodeficiency Virus" by people in this website by year, and whether "Ribonuclease H, Human Immunodeficiency Virus" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 3 | 0 | 3 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Ribonuclease H, Human Immunodeficiency Virus" by people in Profiles.
-
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker. Eur J Med Chem. 2019 Mar 15; 166:390-399.
-
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H. Eur J Med Chem. 2018 Aug 05; 156:680-691.
-
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity. Eur J Med Chem. 2018 Aug 05; 156:652-665.
-
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H. Eur J Med Chem. 2017 Dec 01; 141:149-161.
-
Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity. J Med Chem. 2017 06 22; 60(12):5045-5056.
-
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase. Eur J Med Chem. 2017 Mar 10; 128:168-179.
-
Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H. J Med Chem. 2016 05 26; 59(10):5051-62.
-
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations. J Med Chem. 2016 Mar 24; 59(6):2648-59.
-
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. J Med Chem. 2015 Jan 22; 58(2):651-64.