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Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.
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Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J Med Chem. 2015 Feb 26; 58(4):1976-91.
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subject areas
Administration, Oral
Animals
Antineoplastic Agents
Cell Proliferation
Crystallography, X-Ray
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Discovery
Mice
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Models, Molecular
Molecular Conformation
Protein Kinase Inhibitors
Pyridones
Rats
Small Molecule Libraries
Structure-Activity Relationship
Xenograft Model Antitumor Assays
authors with profiles
John Keith Moffat