Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 6 | 6 |
| 1996 | 0 | 8 | 8 |
| 1997 | 0 | 8 | 8 |
| 1998 | 0 | 7 | 7 |
| 1999 | 0 | 7 | 7 |
| 2000 | 0 | 7 | 7 |
| 2001 | 0 | 13 | 13 |
| 2002 | 0 | 7 | 7 |
| 2003 | 0 | 17 | 17 |
| 2004 | 0 | 16 | 16 |
| 2005 | 1 | 12 | 13 |
| 2006 | 0 | 11 | 11 |
| 2007 | 0 | 15 | 15 |
| 2008 | 0 | 10 | 10 |
| 2009 | 0 | 11 | 11 |
| 2010 | 0 | 10 | 10 |
| 2011 | 0 | 10 | 10 |
| 2012 | 1 | 12 | 13 |
| 2013 | 0 | 18 | 18 |
| 2014 | 0 | 11 | 11 |
| 2015 | 0 | 15 | 15 |
| 2016 | 0 | 13 | 13 |
| 2017 | 0 | 16 | 16 |
| 2018 | 0 | 11 | 11 |
| 2019 | 1 | 12 | 13 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 13 | 13 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 3 | 3 |
| 2024 | 0 | 3 | 3 |
| 2025 | 0 | 3 | 3 |
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click here.
Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. Bioorg Med Chem Lett. 2025 Sep 01; 125-126:130286.
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Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). J Med Chem. 2025 Feb 27; 68(4):4961-4987.
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Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase. Eur J Med Chem. 2025 Apr 05; 287:117335.
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Exploring the rhodanine universe: Design and synthesis of fluorescent rhodanine-based derivatives as anti-fibrillar and anti-oligomer agents against a-synuclein and 2N4R tau. Bioorg Med Chem. 2024 Dec 15; 116:117990.
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A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma. J Med Chem. 2024 Sep 12; 67(17):15428-15437.
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Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 05 09; 67(9):6938-6951.
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5-((3-Amidobenzyl)oxy)nicotinamides as SIRT2 Inhibitors: A Study of Constrained Analogs. Molecules. 2023 Nov 18; 28(22).
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Immunosuppressive effects of new thiophene-based KV1.3 inhibitors. Eur J Med Chem. 2023 Nov 05; 259:115561.
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Asymmetric Total Synthesis of (+)-Phainanoid A and Biological Evaluation of the Natural Product and Its Synthetic Analogues. J Am Chem Soc. 2023 03 01; 145(8):4828-4852.
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XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).