Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 9 | 9 |
| 1995 | 0 | 6 | 6 |
| 1996 | 0 | 8 | 8 |
| 1997 | 0 | 8 | 8 |
| 1998 | 0 | 7 | 7 |
| 1999 | 0 | 7 | 7 |
| 2000 | 0 | 7 | 7 |
| 2001 | 0 | 13 | 13 |
| 2002 | 0 | 7 | 7 |
| 2003 | 0 | 17 | 17 |
| 2004 | 0 | 16 | 16 |
| 2005 | 1 | 12 | 13 |
| 2006 | 0 | 11 | 11 |
| 2007 | 0 | 15 | 15 |
| 2008 | 0 | 10 | 10 |
| 2009 | 0 | 11 | 11 |
| 2010 | 0 | 10 | 10 |
| 2011 | 0 | 10 | 10 |
| 2012 | 1 | 10 | 11 |
| 2013 | 0 | 18 | 18 |
| 2014 | 0 | 11 | 11 |
| 2015 | 0 | 15 | 15 |
| 2016 | 0 | 13 | 13 |
| 2017 | 0 | 15 | 15 |
| 2018 | 0 | 9 | 9 |
| 2019 | 0 | 11 | 11 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 9 | 9 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 May 09; 67(9):6938-6951.
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Immunosuppressive effects of new thiophene-based KV1.3 inhibitors. Eur J Med Chem. 2023 Nov 05; 259:115561.
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Asymmetric Total Synthesis of (+)-Phainanoid A and Biological Evaluation of the Natural Product and Its Synthetic Analogues. J Am Chem Soc. 2023 03 01; 145(8):4828-4852.
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XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).
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Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep. 2021 11 02; 37(5):109940.
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Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. J Med Chem. 2021 11 11; 64(21):15593-15607.
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Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations. Cancer Res. 2021 09 15; 81(18):4685-4695.
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1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure. ChemMedChem. 2021 09 16; 16(18):2882-2894.
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Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient. Cardiovasc Res. 2021 07 07; 117(8):1923-1934.
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Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC. Eur J Med Chem. 2021 Nov 15; 224:113672.