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Godley, Lucy
One or more keywords matched the following items that are connected to Godley, Lucy
Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Analysis of Variance
Concept Base Sequence
Concept Genetic Vectors
Concept DNA Mutational Analysis
Concept Genes, Dominant
Concept Genetics, Medical
Concept Models, Molecular
Concept Molecular Sequence Data
Concept Molecular Weight
Concept Repetitive Sequences, Nucleic Acid
Concept Polymorphism, Genetic
Concept Genes, ras
Concept Cluster Analysis
Concept Transcription, Genetic
Concept Genome
Concept Sequence Homology, Amino Acid
Concept Genetic Variation
Concept Leukemia, Myeloid
Concept Gene Library
Concept Nuclear Localization Signals
Concept Genes, BRCA2
Concept Genes, Tumor Suppressor
Concept Leukemia, Myeloid, Acute
Concept Sequence Analysis, DNA
Concept Genes, Reporter
Concept Consensus Sequence
Concept Genetic Association Studies
Concept Single-Cell Analysis
Concept Exome
Concept Histone Code
Concept Microarray Analysis
Concept Oligonucleotide Array Sequence Analysis
Concept Genes, BRCA1
Concept Catalytic Domain
Concept Genetic Diseases, Inborn
Concept Databases, Genetic
Concept Promoter Regions, Genetic
Concept Survival Analysis
Concept Open Reading Frames
Concept Molecular Structure
Concept Genome, Human
Concept Genes, p53
Concept Transcriptome
Concept Molecular Sequence Annotation
Concept Tissue Array Analysis
Concept Cloning, Molecular
Concept Crosses, Genetic
Concept Enhancer Elements, Genetic
Concept Epistasis, Genetic
Concept Genetic Counseling
Concept Genetic Testing
Concept Proto-Oncogenes
Concept Translocation, Genetic
Concept Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Concept Conserved Sequence
Concept Sequence Analysis, RNA
Concept Genetic Predisposition to Disease
Concept Polymorphism, Single Nucleotide
Concept Cytogenetic Analysis
Concept Quantitative Trait Loci
Concept Epigenesis, Genetic
Concept Molecular Dynamics Simulation
Academic Article The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.
Academic Article TTID: A novel gene at 5q31 encoding a protein with titin-like features.
Academic Article Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
Academic Article cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins.
Academic Article Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.
Academic Article Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q).
Academic Article Successful autologous stem cell collection in patients with chronic myeloid leukemia in complete cytogenetic response, with quantitative measurement of BCR-ABL expression in blood, marrow, and apheresis products.
Academic Article Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.
Academic Article A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia.
Academic Article Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation.
Academic Article Therapy-related myeloid leukemia.
Academic Article Deletion of the der(9q) in chronic myeloid leukemia: the controversy continues.
Academic Article High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma.
Academic Article Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia.
Academic Article The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma.
Academic Article Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines.
Academic Article Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant.
Academic Article Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse.
Academic Article Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage.
Academic Article Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Academic Article Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
Academic Article The use of hypomethylating agents in the treatment of hematologic malignancies.
Academic Article DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.
Academic Article High dose cytarabine and mitoxantrone: an effective induction regimen for high-risk acute myeloid leukemia (AML).
Academic Article Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions.
Academic Article Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet?
Academic Article Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
Academic Article A drug that stops traffic at the nuclear border.
Academic Article Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation.
Academic Article Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.
Academic Article The histone code and treatments for acute myeloid leukemia.
Academic Article Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.
Academic Article Molecular biology. Preference by exclusion.
Academic Article Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Academic Article An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Academic Article Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.
Academic Article Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder.
Academic Article HMGA2 levels in CML: reflective of miRNA gene regulation in a hematopoietic tumor?
Academic Article Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
Academic Article 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
Academic Article Profiles in leukemia.
Academic Article Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.
Academic Article Fludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome.
Academic Article Implications of FLT3 mutations in the therapy of acute myeloid leukemia.
Academic Article Getting to the root of the stem cell in mutated chronic myeloid leukemia.
Academic Article Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity.
Academic Article Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
Academic Article Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis.
Academic Article Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.
Academic Article High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis.
Academic Article Perspectives and future directions for epigenetics in hematology.
Academic Article Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits.
Academic Article 2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.
Academic Article Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Academic Article Proposal for the clinical detection and management of patients and their family members with familial myelodysplastic syndrome/acute leukemia predisposition syndromes.
Academic Article Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells.
Academic Article Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.
Academic Article Randomized open-label phase II study of decitabine in patients with low- or intermediate-risk myelodysplastic syndromes.
Academic Article TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
Academic Article Cell characterization using a protein-functionalized pore.
Academic Article Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma.
Academic Article New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.
Academic Article Node-pore sensing enables label-free surface-marker profiling of single cells.
Academic Article Inherited predisposition to acute myeloid leukemia.
Academic Article DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
Academic Article Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Academic Article Recognizing familial myeloid leukemia in adults.
Academic Article Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
Academic Article A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia.
Academic Article Large conserved domains of low DNA methylation maintained by Dnmt3a.
Academic Article The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
Academic Article Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes.
Academic Article A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies.
Academic Article Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations.
Academic Article On the origin of leukemic species.
Academic Article The mechanistic role of DNA methylation in myeloid leukemogenesis.
Academic Article Linking the genetic architecture of cytosine modifications with human complex traits.
Academic Article TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.
Academic Article DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
Academic Article Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Academic Article Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.
Academic Article Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.
Academic Article Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Academic Article Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Academic Article Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Academic Article Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning.
Academic Article Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC).
Academic Article Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes.
Academic Article Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy.
Academic Article Genetic predisposition to leukemia and other hematologic malignancies.
Academic Article A multicenter phase II trial of the decitabine alternative 5-day dosing regimen: Analysis of efficacy in various subgroups of patients with myelodysplastic syndromes (MDS).
Academic Article How I diagnose and manage individuals at risk for inherited myeloid malignancies.
Academic Article Efficacy of single-agent decitabine in relapsed and refractory acute myeloid leukemia.
Academic Article Germline ETV6 mutations and predisposition to hematological malignancies.
Academic Article Genetic predisposition to hematologic malignancies: management and surveillance.
Academic Article Recognition of familial myeloid neoplasia in adults.
Academic Article Therapy-related myeloid neoplasms: when genetics and environment collide.
Academic Article Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies.
Academic Article Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.
Academic Article Hereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies.
Academic Article MBD4: guardian of the epigenetic galaxy.
Academic Article Reduced-Intensity Allogeneic Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome Using Combined CD34-Selected Haploidentical Graft and a Single Umbilical Cord Unit Compared with Matched Unrelated Donor Stem Cells in Older Adults.
Academic Article Identifying patients with genetic predisposition to acute myeloid leukemia.
Academic Article A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia.
Academic Article Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.
Academic Article Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes.
Academic Article Somatic mutation panels: Time to clear their names.
Academic Article FouNdER mutations confer risk for leukemias.
Academic Article Inherited predisposition to myeloid malignancies.
Academic Article Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis.
Academic Article ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.
Academic Article A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.
Academic Article How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies.
Academic Article RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.
Academic Article Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome.
Academic Article Inherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome.
Academic Article Assessment of technical heterogeneity among diagnostic tests to detect germline risk variants for hematopoietic malignancies.
Academic Article Regulation of telomeric function by DNA methylation differs between humans and mice.
Academic Article Identifying potential germline variants from sequencing hematopoietic malignancies.
Academic Article Identifying potential germline variants from sequencing hematopoietic malignancies.
Academic Article Germline mutations in MDS/AML predisposition disorders.
Academic Article Germline variants drive myelodysplastic syndrome in young adults.
Academic Article Inherited predisposition to haematopoietic malignancies: overcoming barriers and exploring opportunities.
Academic Article Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer.
Academic Article RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.
Academic Article Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model.
Academic Article Clinical features and survival outcomes in patients with chronic myelomonocytic leukemia arising in the context of germline predisposition syndromes.
Academic Article Germline predisposition to hematopoietic malignancies.
Academic Article The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy.
Academic Article Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites.
Academic Article Genetics of Myelodysplastic Syndromes.
Academic Article Therapy-related myeloid neoplasms in 109 patients after radiation monotherapy.
Academic Article Inherited Susceptibility to Hematopoietic Malignancies in the Era of Precision Oncology.
Academic Article The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Academic Article A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias.
Academic Article Feasibility and limitations of cultured skin fibroblasts for germline genetic testing in hematologic disorders.
Academic Article Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.
Academic Article Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Academic Article Revision of RUNX1 variant curation rules.
Academic Article Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Academic Article Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors.
Academic Article Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.
Academic Article Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages.
Academic Article DDX41-associated susceptibility to myeloid neoplasms.
Academic Article Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.
Academic Article (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
Grant The Role of DNMT3B in the DNA Methylation of Cancer Cells
Grant A chemical crosslinking strategy to determine DNA methylating protein complexes
Grant Epigenetic and Genetic Dissection of Drug Response
Academic Article Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation.
Academic Article Sequential tumor molecular profiling identifies likely germline variants.
Academic Article Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population.
Academic Article Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.
Academic Article Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders.
Search Criteria
  • Molecular
  • analysis
  • genetic
  • pathways
  • leading
  • myeloid leukemias