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Gurbuxani, Sandeep

One or more keywords matched the following properties of Gurbuxani, Sandeep

Property	Value
keywords	Acute Lymphoblastic Leukemia
keywords	Mouse models of Hematologic Malignancies
overview	As an attending hematopathologist I am involved in diagnostic work up and follow up after therapy of patients diagnosed with hematologic malignancies including AML, ALL, MDS and MDS/MPN. I am interested in understanding the pathogenesis of hematopoietic tumors and how specific events required for leukemic transformation can be targeted for therapy. In addition, as part of collaborative research projects I have been involved in the analyses of mice in models of normal and malignant hematopoiesis.

One or more keywords matched the following items that are connected to Gurbuxani, Sandeep

Item Type	Name
Concept	Chromosomes, Human, Pair 8
Concept	Chromosomes, Human, Pair 1
Concept	Chromosomes, Human, Pair 21
Concept	Chromosomes, Human, Pair 5
Concept	Leukemia, Erythroblastic, Acute
Concept	Leukemia
Concept	Leukemia, Megakaryoblastic, Acute
Concept	Influenza, Human
Concept	Herpesvirus 4, Human
Concept	Models, Molecular
Concept	Mice, Transgenic
Concept	Models, Genetic
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred C57BL
Concept	Leukemia, B-Cell
Concept	Humans
Concept	Leukemia, Myeloid
Concept	Leukemia, Myeloid, Acute
Concept	Mice, Knockout
Concept	Mice
Concept	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Concept	Leukemia, Promyelocytic, Acute
Concept	Leukemia-Lymphoma, Adult T-Cell
Concept	Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept	Myeloid-Lymphoid Leukemia Protein
Concept	Disease Models, Animal
Concept	Leukemia, Hairy Cell
Concept	Mice, Mutant Strains
Concept	Models, Biological
Concept	Herpesvirus 8, Human
Academic Article	Detection of BCR-ABL transcripts in acute lymphoblastic leukemia in Indian patients.
Academic Article	Hsp27 negatively regulates cell death by interacting with cytochrome c.
Academic Article	Expression of genes implicated in multidrug resistance in acute lymphoblastic leukemia in India.
Academic Article	Heat-shock protein 70 antagonizes apoptosis-inducing factor.
Academic Article	Significance of MDR1, MRP1, GSTpi and GSTmu mRNA expression in acute lymphoblastic leukemia in Indian patients.
Academic Article	Incidence, clinical characteristics and early treatment outcome in Indian patients of childhood acute lymphoblastic leukemia with ALL-1 gene rearrangement.
Academic Article	Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways.
Academic Article	Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis.
Academic Article	Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome.
Academic Article	HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation.
Academic Article	Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C.
Academic Article	Heat shock proteins: endogenous modulators of apoptotic cell death.
Academic Article	Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.
Academic Article	Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome.
Academic Article	WT1 expression in myelodysplastic syndrome.
Academic Article	Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.
Academic Article	Resident training in laboratory hematology.
Academic Article	Extranodal hairy cell leukemia presenting in the lumbar spine.
Academic Article	CD36 - a marker for drug sensitive acute megakaryoblastic leukemia.
Academic Article	What to do when you suspect gastrointestinal lymphoma: a pathologist's perspective.
Academic Article	Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells.
Academic Article	High dose cytarabine and mitoxantrone: an effective induction regimen for high-risk acute myeloid leukemia (AML).
Academic Article	MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.
Academic Article	FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis.
Academic Article	E2A proteins promote development of lymphoid-primed multipotent progenitors.
Academic Article	Intracranial mucosa-associated lymphoid tissue (MALT) lymphoma.
Academic Article	An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Academic Article	FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis.
Academic Article	Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.
Academic Article	Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemia.
Academic Article	Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article	CHOP plus alemtuzumab can induce metabolic response by FDG-PET but has minimal long-term benefits: a case report and literature review.
Academic Article	Overexpression of survivin initiates hematologic malignancies in vivo.
Academic Article	Pattern of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements in childhood acute lymphoblastic leukemia in India.
Academic Article	Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells.
Academic Article	Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.
Academic Article	Differential requirements for survivin in hematopoietic cell development.
Academic Article	CHOP plus alemtuzumab can induce metabolic response by FDG-PET but has minimal long-term benefits: a case report and literature review.
Academic Article	Diffuse large B-cell lymphoma--more than a diffuse collection of large B cells: an entity in search of a meaningful classification.
Academic Article	Expression of the multidrug resistance-associated protein (MRP) mRNA and protein in normal peripheral blood and bone marrow haemopoietic cells.
Academic Article	MDR1 mRNA expression in young patients with acute lymphoblastic leukaemia.
Academic Article	MDR1/P-glycoprotein in haematological neoplasms.
Academic Article	A prospective study on the incidence of hepatitis B & C infections amongst patients with lymphoproliferative disorders.
Academic Article	On a WHIM.
Academic Article	TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article	miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.
Academic Article	RCSD1-ABL2 fusion resulting from a complex chromosomal rearrangement in high-risk B-cell acute lymphoblastic leukemia.
Academic Article	Stem cell factor expression in B cell malignancies is influenced by the niche.
Academic Article	A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.
Academic Article	AKT is a therapeutic target in myeloproliferative neoplasms.
Academic Article	Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Academic Article	A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies.
Academic Article	PLZF staining identifies peripheral T-cell lymphomas derived from innate-like T-cells with TRAV1-2-TRAJ33 TCR-a rearrangement.
Academic Article	Cloaked in a starry sky.
Academic Article	Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation.
Academic Article	Overexpression and knockout of miR-126 both promote leukemogenesis.
Academic Article	Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Academic Article	PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.
Academic Article	Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article	miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.
Academic Article	Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles.
Academic Article	Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.
Academic Article	Peripheral T-cell lymphomas of follicular helper T-cell type frequently display an aberrant CD3(-/dim)CD4(+) population by flow cytometry: an important clue to the diagnosis of a Hodgkin lymphoma mimic.
Academic Article	Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL).
Academic Article	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Academic Article	Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis.
Academic Article	The web of microRNA in B lymphoblastic leukemia.
Academic Article	Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS.
Academic Article	A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands.
Academic Article	Head and Neck Sinus Histiocytosis with Massive Lymphadenopathy Radiology-Pathology Correlation.
Academic Article	Immune Reconstitution Following Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma at the Time of Immunotherapy.
Academic Article	Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial.
Academic Article	Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks.
Academic Article	Lymphoblastic leukemia following MDS or MDS/MPN: clinical evidence for stem cell origins of these disorders.
Academic Article	Clinical outcomes of IDH2-mutated advanced-phase Ph-negative myeloproliferative neoplasms treated with enasidenib.
Academic Article	Carfilzomib, lenalidomide, and dexamethasone plus transplant in newly diagnosed multiple myeloma.
Academic Article	CXCL4's "Gliful" subversion of BM in MPN.
Academic Article	LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.
Academic Article	A series of COVID-19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza.
Academic Article	bcr3 PML-RARA: short fusion, small blasts!
Academic Article	Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.
Academic Article	Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation.
Academic Article	MUC4 expression by immunohistochemistry is a specific marker for BCR-ABL1+ and BCR-ABL1-like B-lymphoblastic leukemia.
Academic Article	Therapy-related myeloid neoplasms with normal karyotype show distinct genomic and clinical characteristics compared to their counterparts with abnormal karyotype.
Academic Article	GLUT1 Immunohistochemistry Is a Highly Sensitive and Relatively Specific Marker for Erythroid Lineage in Benign and Malignant Hematopoietic Tissues.
Academic Article	B-cell lymphoma-2 downregulation is a useful feature supporting a neoplastic phenotype in mature T-cell lymphomas.
Academic Article	Type I but Not Type II Calreticulin Mutations Activate the IRE1a/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms.
Academic Article	Efficacy and tolerability of a modified pediatric-inspired intensive regimen for acute lymphoblastic leukemia in older adults.
Academic Article	Elotuzumab and Weekly Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Without Transplant Intent: A Phase 2 Measurable Residual Disease-Adapted Study.
Academic Article	Outcomes After Retreatment With Inotuzumab Ozogamicin for Relapsed/Refractory Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia.
Academic Article	Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus.
Academic Article	Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors.
Academic Article	IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms.
Academic Article	Gata1s mutant mice display persistent defects in the erythroid lineage.
Academic Article	Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents.
Academic Article	NPM1 exon 5 mutations in acute myeloid leukemia: Implications in diagnosis and minimal residual monitoring.
Academic Article	Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.
Academic Article	EBV-positive inflammatory FDC/FRC tumor: no longer pseudo or sarcoma!
Concept	Promyelocytic Leukemia Zinc Finger Protein
Academic Article	The Times, They Are A-Changing: The Impact of Next-Generation Sequencing on Diagnosis, Classification, and Prognostication of Myeloid Malignancies With Focus on Myelodysplastic Syndrome, AML, and Germline Predisposition.
Academic Article	Microbiota may affect the tumor type but not overall tumor development in two models of heritable cancer.
Academic Article	Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults.
Academic Article	Durable responses in acute lymphoblastic leukaemia with the use of FLT3 and IDH inhibitors.
Academic Article	Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.
Academic Article	SETBP1 sets the stage.

Search Criteria

Development
mouse
models
human
leukemias