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Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
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Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition. Nat Med. 2015 Dec; 21(12):1473-80.
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subject areas
Animals
Antigens, CD34
Apoptosis
Aurora Kinase A
Azepines
Blotting, Western
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Cost of Illness
Disease Models, Animal
Drug Synergism
Heterozygote
Inhibitory Concentration 50
Janus Kinase 2
Megakaryocytes
Mice
Mutation
Nitriles
Polyploidy
Primary Myelofibrosis
Protein Kinase Inhibitors
Proto-Oncogene Proteins c-myc
Pyrazoles
Pyrimidines
Receptors, Thrombopoietin
Signal Transduction
authors with profiles
Sandeep Gurbuxani