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One or more keywords matched the following properties of Spitz, Francois
keywords Gene Expression Regulation
keywords Gene Regulatory Networks
overview Our group is interested in understanding how the architecture of the genome contributes to the specificity and robustness of the gene expression programs that govern embryonic development and cell differentiation. Vertebrate genomes contain hundreds of thousands of regulatory sequences that can influence the expression of genes sometimes located hundreds of kilobases away. Our main goal is to understand how the folding of the genome in specific domains and dynamic structures contributes to transform such a dispersed information into highly specific regulatory ensembles. We study as well how perturbations of these processes, notably due to chromosomal rearrangements, could lead to developmental or oncogenic pathologies, but may have also participated to animal evolution.
One or more keywords matched the following items that are connected to Spitz, Francois
Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Genes, Homeobox
Concept Genes, Synthetic
Concept Lac Operon
Concept Genes, Switch
Concept Multigene Family
Concept Molecular Sequence Data
Concept Repetitive Sequences, Nucleic Acid
Concept Genes, Intracisternal A-Particle
Concept Sequence Homology, Nucleic Acid
Concept Genome
Concept Gene Duplication
Concept Up-Regulation
Concept Gene Expression
Concept Genes, Reporter
Concept Consensus Sequence
Concept Gene Transfer Techniques
Concept Gene Deletion
Concept Gene Expression Regulation, Developmental
Concept Transgenes
Concept Gene Expression Profiling
Concept Gene Order
Concept Genes, Developmental
Concept Down-Regulation
Concept Genes, myc
Concept Gene Silencing
Concept Gene Dosage
Concept Transcriptome
Concept Epistasis, Genetic
Concept Conserved Sequence
Concept Genetic Loci
Academic Article Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase.
Academic Article A regulatory archipelago controls Hox genes transcription in digits.
Academic Article Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences.
Academic Article Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.
Academic Article Fiber-type specific and position-dependent expression of a transgene in limb muscles.
Academic Article A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.
Academic Article Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.
Academic Article An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.
Academic Article A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes.
Academic Article Phenotypic impact of genomic structural variation: insights from and for human disease.
Academic Article Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.
Academic Article Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.
Academic Article Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes.
Academic Article Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype.
Academic Article A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects.
Academic Article Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.
Academic Article Formation of new chromatin domains determines pathogenicity of genomic duplications.
Academic Article Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.
Academic Article A switch between topological domains underlies HoxD genes collinearity in mouse limbs.
Academic Article KAP1 controls endogenous retroviruses in embryonic stem cells.
Academic Article A global control region defines a chromosomal regulatory landscape containing the HoxD cluster.
Academic Article Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations.
Academic Article Developmental regulation of the aldolase A muscle-specific promoter during in vivo muscle maturation is controlled by a nuclear receptor binding element.
Academic Article Control of vertebrate Hox clusters by remote and global cis-acting regulatory sequences.
Academic Article Developmental biology: reproduction in clusters.
Academic Article Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq.
Academic Article Gene regulation at a distance: From remote enhancers to 3D regulatory ensembles.
Academic Article Gene regulation during development in the light of topologically associating domains.
Academic Article The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains.
Academic Article The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.
Academic Article From remote enhancers to gene regulation: charting the genome's regulatory landscapes.
Academic Article Uncoupling time and space in the collinear regulation of Hox genes.
Academic Article Transgenic analysis of Hoxd gene regulation during digit development.
Academic Article The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.
Academic Article Systemic IFN-beta gene therapy results in long-term survival in mice with established colorectal liver metastases.
Academic Article [A STRING lifts the veil on the mechanisms controlling Hox genes expression].
Academic Article Transcription factors: from enhancer binding to developmental control.
Academic Article Global control regions and regulatory landscapes in vertebrate development and evolution.
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  • regulation