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Rhodes, Christopher
One or more keywords matched the following items that are connected to Rhodes, Christopher
Item TypeName
Concept Insulin
Concept Insulin-Like Growth Factor I
Concept Receptor, Insulin
Concept Insulin Resistance
Concept Insulin-Like Growth Factor Binding Protein 1
Concept Insulin-Secreting Cells
Concept Insulin Receptor Substrate Proteins
Concept Insulin, Regular, Human
Academic Article Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
Academic Article Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases.
Academic Article A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
Academic Article Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
Academic Article Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
Academic Article Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
Academic Article Insulin-secreting non-islet cells are resistant to autoimmune destruction.
Academic Article The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
Academic Article Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
Academic Article A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Academic Article Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
Academic Article Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
Academic Article How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats.
Academic Article Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
Academic Article Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
Academic Article A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
Academic Article Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
Academic Article Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
Academic Article Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
Academic Article Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
Academic Article A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
Academic Article Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
Academic Article Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
Academic Article Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
Academic Article Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
Academic Article A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
Academic Article Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
Academic Article Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
Academic Article Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
Academic Article Type 2 diabetes-a matter of beta-cell life and death?
Academic Article 10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?
Academic Article Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
Academic Article Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
Academic Article Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
Academic Article Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
Academic Article Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
Academic Article Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Academic Article Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
Academic Article Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?
Academic Article A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
Academic Article Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
Academic Article Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
Academic Article Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
Academic Article Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Academic Article Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.
Academic Article Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules.
Academic Article [Biogenesis of the insulin secretion granule].
Academic Article Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Academic Article The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
Academic Article Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
Academic Article Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
Academic Article Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
Academic Article The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
Academic Article Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
Academic Article Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
Academic Article Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
Academic Article Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets.
Academic Article AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
Academic Article Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
Academic Article Formation of a human ß-cell population within pancreatic islets is set early in life.
Academic Article Degradation of islet amyloid polypeptide by neprilysin.
Academic Article High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin.
Academic Article How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
Academic Article Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
Academic Article FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
Academic Article A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
Academic Article Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
Academic Article Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.
Academic Article PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
Academic Article Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.
Academic Article Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
Academic Article The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide.
Academic Article Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.
Academic Article Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
Academic Article Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
Academic Article Molecular insights into insulin action and secretion.
Academic Article Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
Academic Article Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
Academic Article IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
Academic Article Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.
Academic Article Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
Academic Article The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
Academic Article Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
Academic Article Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.
Academic Article Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
Academic Article Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
Academic Article Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
Academic Article Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.
Academic Article Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.
Academic Article IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
Academic Article Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Academic Article Intracellular signalling. Key enzyme in leptin-induced anorexia.
Academic Article ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
Academic Article Islet autoantigens: structure, function, localization, and regulation.
Academic Article Direct autocrine action of insulin on ß-cells: does it make physiological sense?
Academic Article ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
Academic Article Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
Academic Article SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
Academic Article Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
Academic Article Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
Academic Article Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Academic Article Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
Academic Article ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats.
Academic Article The dynamic plasticity of insulin production in ß-cells.
Academic Article Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
Academic Article Biosynthesis and storage of insulin.
Academic Article Human PAH is characterized by a pattern of lipid-related insulin resistance.
Academic Article Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
Academic Article Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
Academic Article Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
Academic Article Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
Academic Article A fluorescent timer reporter enables sorting of insulin secretory granules by age.
Academic Article A fluorescent timer reporter enables sorting of insulin secretory granules by age.
Academic Article Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
Academic Article Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.
Grant Mitogenic Signal Transduction in Pancreatic Beta-Cells
Grant Metabolic Control of Insulin Exocytosis
Grant Central Control of Pancreatic Islet Function
Grant Western Region Islet Study Group
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Grant Metabolic Control of Proinsulin Biosynthesis Translation
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  • Insulin